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Ttpa tocopherol (alpha) transfer protein [ Mus musculus (house mouse) ]

Gene ID: 50500, updated on 5-Dec-2017
Official Symbol
Ttpaprovided by MGI
Official Full Name
tocopherol (alpha) transfer proteinprovided by MGI
Primary source
MGI:MGI:1354168
See related
Ensembl:ENSMUSG00000073988 Vega:OTTMUSG00000006384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
alpha-TTP
Expression
Biased expression in liver adult (RPKM 49.2) and liver E18 (RPKM 17.0) See more
Orthologs
Location:
4 A3; 4 7.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (20007909..20030822)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (19935575..19957932)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit D2 Neighboring gene RIKEN cDNA 4930480G23 gene Neighboring gene uncharacterized LOC105247101 Neighboring gene gamma-glutamyl hydrolase

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
intermembrane lipid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
vitamin E binding IDA
Inferred from Direct Assay
more info
PubMed 
vitamin E binding ISO
Inferred from Sequence Orthology
more info
 
vitamin E binding TAS
Traceable Author Statement
more info
PubMed 
vitamin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intermembrane lipid transfer IDA
Inferred from Direct Assay
more info
PubMed 
intracellular pH reduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of establishment of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to pH ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
vitamin E metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vitamin E metabolic process ISO
Inferred from Sequence Orthology
more info
 
vitamin transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
alpha-tocopherol transfer protein
Names
alpha TTP

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317723.1NP_001304652.1  alpha-tocopherol transfer protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in a novel 5' UTR, and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared isoform 1.
    Source sequence(s)
    AL732527
    Consensus CDS
    CCDS84707.1
    UniProtKB/TrEMBL
    A8Y5N9
    Related
    ENSMUSP00000113966.1, OTTMUSP00000020368, ENSMUST00000121491.7, OTTMUST00000014516
    Conserved Domains (1) summary
    pfam00650
    Location:30179
    CRAL_TRIO; CRAL/TRIO domain
  2. NM_015767.4NP_056582.1  alpha-tocopherol transfer protein isoform 1

    See identical proteins and their annotated locations for NP_056582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK004882, AK050374, AL732527, AV026942, BY072913
    Consensus CDS
    CCDS17995.1
    UniProtKB/Swiss-Prot
    Q8BWP5
    UniProtKB/TrEMBL
    Q499J3
    Related
    ENSMUSP00000095845.1, ENSMUST00000098244.1
    Conserved Domains (2) summary
    smart01100
    Location:2573
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:99248
    CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    20007909..20030822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320306.1XP_017175795.1  alpha-tocopherol transfer protein isoform X1

    UniProtKB/TrEMBL
    A8Y5N9
    Conserved Domains (1) summary
    pfam00650
    Location:30179
    CRAL_TRIO; CRAL/TRIO domain
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