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P2RY4 pyrimidinergic receptor P2Y4 [ Homo sapiens (human) ]

Gene ID: 5030, updated on 8-Jul-2021

Summary

Official Symbol
P2RY4provided by HGNC
Official Full Name
pyrimidinergic receptor P2Y4provided by HGNC
Primary source
HGNC:HGNC:8542
See related
Ensembl:ENSG00000186912 MIM:300038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRU; P2P; UNR; P2Y4
Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See P2RY4 in Genome Data Viewer
Location:
Xq13.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (70258166..70260204, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69478016..69480054, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene RNA, 5S ribosomal pseudogene 507 Neighboring gene arrestin 3 Neighboring gene RAB41, member RAS oncogene family Neighboring gene PDZ domain containing 11

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled UTP receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P2Y purinoceptor 4
Names
pyrimidinergic receptor P2Y, G-protein coupled, 4
uridine nucleotide receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013250.1 RefSeqGene

    Range
    5001..6639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002565.4NP_002556.1  P2Y purinoceptor 4

    See identical proteins and their annotated locations for NP_002556.1

    Status: REVIEWED

    Source sequence(s)
    AL357752
    Consensus CDS
    CCDS14398.1
    UniProtKB/Swiss-Prot
    P51582
    Related
    ENSP00000363643.2, ENST00000374519.4
    Conserved Domains (1) summary
    cd15374
    Location:36317
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    70258166..70260204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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