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OR3A2 olfactory receptor family 3 subfamily A member 2 [ Homo sapiens (human) ]

Gene ID: 4995, updated on 13-May-2022

Summary

Official Symbol
OR3A2provided by HGNC
Official Full Name
olfactory receptor family 3 subfamily A member 2provided by HGNC
Primary source
HGNC:HGNC:8283
See related
Ensembl:ENSG00000221882 AllianceGenome:HGNC:8283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR228; OLFRA04; OR17-14; OR17-228
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 1.2), brain (RPKM 0.2) and 1 other tissue See more
Orthologs
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Genomic context

See OR3A2 in Genome Data Viewer
Location:
17p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3276113..3386308, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3164339..3275247, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3179407..3289602, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily D member 4 Neighboring gene olfactory receptor family 1 subfamily D member 3 pseudogene Neighboring gene olfactory receptor family 3 subfamily A member 1 Neighboring gene olfactory receptor family 3 subfamily A member 4 pseudogene Neighboring gene olfactory receptor family 3 subfamily A member 5 pseudogene Neighboring gene olfactory receptor family 1 subfamily AC member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily R member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene olfactory receptor family 3 subfamily A member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 3A2
Names
olfactory receptor 17-228
olfactory receptor OR17-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002551.4NP_002542.4  olfactory receptor 3A2

    Status: VALIDATED

    Source sequence(s)
    AC087498
    Consensus CDS
    CCDS42233.1
    Related
    ENSP00000493441.1, ENST00000642052.1
    Conserved Domains (1) summary
    cd15233
    Location:28304
    7tmA_OR3A-like; olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3276113..3386308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436157.1XP_047292113.1  olfactory receptor 3A2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3164339..3275247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)