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WRAP73 WD repeat containing, antisense to TP73 [ Homo sapiens (human) ]

Gene ID: 49856, updated on 1-Jun-2020

Summary

Official Symbol
WRAP73provided by HGNC
Official Full Name
WD repeat containing, antisense to TP73provided by HGNC
Primary source
HGNC:HGNC:12759
See related
Ensembl:ENSG00000116213 MIM:606040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR8
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 7.8), testis (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See WRAP73 in Genome Data Viewer
Location:
1p36.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (3630767..3650103, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3547331..3566671, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 6 Neighboring gene uncharacterized LOC105378607 Neighboring gene tumor protein p63 regulated 1 like Neighboring gene TP73 antisense RNA 3 Neighboring gene uncharacterized LOC105378609 Neighboring gene tumor protein p73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20430, MGC99569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
microtubule anchoring at mitotic spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to mitotic spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MWP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein WRAP73
Names
WD repeat domain 8
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033937.1 RefSeqGene

    Range
    5005..24338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017818.4NP_060288.3  WD repeat-containing protein WRAP73

    See identical proteins and their annotated locations for NP_060288.3

    Status: REVIEWED

    Source sequence(s)
    AI376011, BC086311, DC380547
    Consensus CDS
    CCDS48.1
    UniProtKB/Swiss-Prot
    Q9P2S5
    Related
    ENSP00000270708.7, ENST00000270708.12
    Conserved Domains (2) summary
    COG2319
    Location:49438
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1447
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    3630767..3650103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244754.2XP_005244811.1  WD repeat-containing protein WRAP73 isoform X2

    See identical proteins and their annotated locations for XP_005244811.1

    Conserved Domains (3) summary
    COG2319
    Location:13360
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1447
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:14356
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017001387.2XP_016856876.1  WD repeat-containing protein WRAP73 isoform X1

RNA

  1. XR_946661.3 RNA Sequence

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