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ATP4A ATPase H+/K+ transporting subunit alpha [ Homo sapiens (human) ]

Gene ID: 495, updated on 22-Sep-2022

Summary

Official Symbol
ATP4Aprovided by HGNC
Official Full Name
ATPase H+/K+ transporting subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:819
See related
Ensembl:ENSG00000105675 MIM:137216; AllianceGenome:HGNC:819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP6A
Summary
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward stomach (RPKM 218.2) See more
Orthologs
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Genomic context

See ATP4A in Genome Data Viewer
Location:
19q13.12
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35550031..35563658, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38094977..38108614, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36040933..36054560, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene TMEM147 antisense RNA 1 Neighboring gene transmembrane protein 147 Neighboring gene uncharacterized LOC124904704 Neighboring gene PMIS2 transmembrane protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables P-type potassium:proton transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables P-type potassium:proton transporter activity TAS
Traceable Author Statement
more info
 
enables P-type sodium:potassium-exchanging transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables potassium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in pH reduction IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of proton transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
potassium-transporting ATPase alpha chain 1
Names
ATPase H+/K+ transporting alpha subunit
ATPase, H+/K+ exchanging, alpha polypeptide
ATPase, H+/K+ transporting, alpha polypeptide
epididymis secretory sperm binding protein
gastric H+/K+ ATPase alpha subunit
gastric H,K-ATPase catalytic subunit
gastric hydrogen-potassium ATPase
proton pump
NP_000695.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000704.3NP_000695.2  potassium-transporting ATPase alpha chain 1

    See identical proteins and their annotated locations for NP_000695.2

    Status: REVIEWED

    Source sequence(s)
    AC002389, AK058032, AL832971
    Consensus CDS
    CCDS12467.1
    UniProtKB/Swiss-Prot
    O00738, P20648
    UniProtKB/TrEMBL
    A0A384MR29, Q658V6
    Related
    ENSP00000262623.2, ENST00000262623.4
    Conserved Domains (2) summary
    TIGR01106
    Location:431035
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam09040
    Location:222
    H-K_ATPase_N; Gastric H+/K+-ATPase, N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35550031..35563658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38094977..38108614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)