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PPDPFL pancreatic progenitor cell differentiation and proliferation factor like [ Homo sapiens (human) ]

Gene ID: 492307, updated on 5-Aug-2022

Summary

Official Symbol
PPDPFLprovided by HGNC
Official Full Name
pancreatic progenitor cell differentiation and proliferation factor likeprovided by HGNC
Primary source
HGNC:HGNC:31745
See related
Ensembl:ENSG00000168333 AllianceGenome:HGNC:31745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8orf22
Summary
Predicted to be involved in cell differentiation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in prostate (RPKM 1.7), esophagus (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

See PPDPFL in Genome Data Viewer
Location:
8q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (49054336..49076093)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (49432165..49453922)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (49966895..49988652)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986942 Neighboring gene snail family transcriptional repressor 2 Neighboring gene uncharacterized LOC105375826 Neighboring gene Sharpr-MPRA regulatory region 5408

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pancreatic progenitor cell differentiation and proliferation factor-like protein
Names
exocrine differentiation and proliferation factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007176.5NP_001007177.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform a

    See identical proteins and their annotated locations for NP_001007177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (a).
    Source sequence(s)
    AC044893, BC017981, DA820911
    Consensus CDS
    CCDS47854.1
    UniProtKB/Swiss-Prot
    Q8WWR9
    Related
    ENSP00000382561.4, ENST00000399653.8
    Conserved Domains (1) summary
    pfam15060
    Location:169
    PPDFL; Differentiation and proliferation regulator
  2. NM_001256596.1NP_001243525.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform b

    See identical proteins and their annotated locations for NP_001243525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a longer and distinct C-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC044893, BC017981, BG202040
    Consensus CDS
    CCDS59102.1
    UniProtKB/Swiss-Prot
    Q8WWR9
    Related
    ENSP00000430392.1, ENST00000517663.5
    Conserved Domains (1) summary
    pfam15060
    Location:182
    PPDFL; Differentiation and proliferation regulator
  3. NM_001256597.2NP_001243526.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform b

    See identical proteins and their annotated locations for NP_001243526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a longer and distinct C-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC044893, BC017981, DA900243
    Consensus CDS
    CCDS59102.1
    UniProtKB/Swiss-Prot
    Q8WWR9
    Related
    ENSP00000428773.1, ENST00000522267.6
    Conserved Domains (1) summary
    pfam15060
    Location:182
    PPDFL; Differentiation and proliferation regulator
  4. NM_001256598.2NP_001243527.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform c

    See identical proteins and their annotated locations for NP_001243527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform c, which has a longer and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC044893, AJ276240, BC017981, DA820911
    Consensus CDS
    CCDS59101.1
    UniProtKB/Swiss-Prot
    Q8WVI1, Q8WWR9
    Related
    ENSP00000304926.8, ENST00000303202.8
    Conserved Domains (1) summary
    pfam15060
    Location:169
    PPDFL; Differentiation and proliferation regulator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    49054336..49076093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    49432165..49453922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)