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NTSR1 neurotensin receptor 1 [ Homo sapiens (human) ]

Gene ID: 4923, updated on 4-Jun-2020

Summary

Official Symbol
NTSR1provided by HGNC
Official Full Name
neurotensin receptor 1provided by HGNC
Primary source
HGNC:HGNC:8039
See related
Ensembl:ENSG00000101188 MIM:162651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTR
Summary
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NTSR1 in Genome Data Viewer
Location:
20q13.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (62708770..62762771)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61340189..61394123)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928465 Neighboring gene solute carrier organic anion transporter family member 4A1 Neighboring gene SLCO4A1 antisense RNA 1 Neighboring gene uncharacterized LOC107987285 Neighboring gene uncharacterized LOC107985428 Neighboring gene long intergenic non-protein coding RNA 659 Neighboring gene uncharacterized LOC105372716

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled neurotensin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled neurotensin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
D-aspartate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
learning IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cation channel activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gamma-aminobutyric acid secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inhibitory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
regulation of respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
response to lipid IEA
Inferred from Electronic Annotation
more info
 
temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
symmetric synapse IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neurotensin receptor type 1
Names
NT-R-1
NTR1
NTRH
high-affinity levocabastine-insensitive neurotensin receptor
neurotensin receptor 1 (high affinity)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002531.3NP_002522.2  neurotensin receptor type 1

    See identical proteins and their annotated locations for NP_002522.2

    Status: REVIEWED

    Source sequence(s)
    AL035669, AL357033, BC040711, X70070
    Consensus CDS
    CCDS13502.1
    UniProtKB/Swiss-Prot
    P30989
    Related
    ENSP00000359532.3, ENST00000370501.4
    Conserved Domains (2) summary
    pfam00001
    Location:80364
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:159381
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    62708770..62762771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528827.2XP_011527129.1  neurotensin receptor type 1 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:80336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:143267
    7tm_4; Olfactory receptor
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