NTSR1 neurotensin receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTSR1provided by HGNC
Official Full Name: neurotensin receptor 1provided by HGNC
Primary source: HGNC:HGNC:8039
See related: Ensembl:ENSG00000101188 MIM:162651; AllianceGenome:HGNC:8039
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NTR
Summary: Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 20q13.33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (62708836..62762771)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (64507559..64561762)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (61340188..61394123)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein.
Title: NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein.
Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3.
Title: Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3.
Neurotensin receptor 1 signaling promotes pancreatic cancer progression.
Title: Neurotensin receptor 1 signaling promotes pancreatic cancer progression.
Effect of NTSR1 on the Proliferation and Invasion of Gastric Adenocarcinoma Cells, the Underlying Mechanism, and Clinical Role.
Title: Effect of NTSR1 on the Proliferation and Invasion of Gastric Adenocarcinoma Cells, the Underlying Mechanism, and Clinical Role.
Feeling at home: Structure of the NTSR1-Gi complex in a lipid environment.
Title: Feeling at home: Structure of the NTSR1-G(i) complex in a lipid environment.
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Title: Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
Title: Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
beta-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Title: β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling.
Title: Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling.
Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer.
Title: Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:455350 (e-PCR)
- UniSTS:157460

RH75982 (e-PCR)
- UniSTS:87526

RH70884 (e-PCR)
- UniSTS:90102

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled neurotensin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled neurotensin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled neurotensin receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled neurotensin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-aspartate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in associative learning	IEA Inferred from Electronic Annotation more info
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in conditioned place preference	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in inositol phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in learning	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gamma-aminobutyric acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inhibitory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of locomotion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inositol trisphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of respiratory gaseous exchange	IEA Inferred from Electronic Annotation more info
involved_in response to food	IEA Inferred from Electronic Annotation more info
involved_in response to lipid	IEA Inferred from Electronic Annotation more info
involved_in response to stress	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	IEA Inferred from Electronic Annotation more info
involved_in vocalization behavior	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in neuron spine	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in symmetric synapse	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurotensin receptor type 1

Names: NT-R-1; NTR1; NTRH; high-affinity levocabastine-insensitive neurotensin receptor; neurotensin receptor 1 (high affinity)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.