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ROR1 receptor tyrosine kinase like orphan receptor 1 [ Homo sapiens (human) ]

Gene ID: 4919, updated on 4-Jun-2020

Summary

Official Symbol
ROR1provided by HGNC
Official Full Name
receptor tyrosine kinase like orphan receptor 1provided by HGNC
Primary source
HGNC:HGNC:10256
See related
Ensembl:ENSG00000185483 MIM:602336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTRKR1; dJ537F10.1
Summary
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues See more
Orthologs

Genomic context

See ROR1 in Genome Data Viewer
Location:
1p31.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (63774017..64181498)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (64239690..64647181)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 1 Neighboring gene uncharacterized LOC105378771 Neighboring gene RNA, 7SL, cytoplasmic 130, pseudogene Neighboring gene ribosomal protein L19 pseudogene 3 Neighboring gene cofilin 1 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 8799 Neighboring gene uncharacterized LOC105378772 Neighboring gene RNA, U6 small nuclear 809, pseudogene Neighboring gene ROR1 antisense RNA 1 Neighboring gene uncharacterized LOC105378773 Neighboring gene ubiquitin conjugating enzyme E2 U

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Wnt-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway, planar cell polarity pathway IEA
Inferred from Electronic Annotation
more info
 
anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
inner ear development ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
NOT positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive tyrosine-protein kinase transmembrane receptor ROR1
Names
neurotrophic tyrosine kinase, receptor-related 1
NP_001077061.1
NP_005003.2
XP_011539828.1
XP_016856865.1
XP_016856866.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032801.2 RefSeqGene

    Range
    4999..412480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083592.2NP_001077061.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001077061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' UTR and lacks an in-frame portion of the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter C-terminus that lacks a tyrosine kinase catalytic domain, compared to isoform 1.
    Source sequence(s)
    AL137859, AL161742, AL445205, BC080541
    Consensus CDS
    CCDS41344.1
    UniProtKB/Swiss-Prot
    Q01973
    Related
    ENSP00000360121.1, ENST00000371080.5
    Conserved Domains (3) summary
    cd07467
    Location:166307
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:311392
    KR; Kringle domain
    smart00410
    Location:66148
    IG_like; Immunoglobulin like
  2. NM_005012.4NP_005003.2  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_005003.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK000776, AK308088, AL137859, AL161742, AL445205, M97675
    Consensus CDS
    CCDS626.1
    UniProtKB/Swiss-Prot
    Q01973
    Related
    ENSP00000360120.1, ENST00000371079.6
    Conserved Domains (4) summary
    cd07467
    Location:166307
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:311393
    KR; Kringle domain
    smart00410
    Location:66148
    IG_like; Immunoglobulin like
    cd05090
    Location:467749
    PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    63774017..64181498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001377.1XP_016856866.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

    Conserved Domains (6) summary
    cd00096
    Location:1280
    Ig; Immunoglobulin domain
    cd07467
    Location:103244
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:248330
    KR; Kringle domain
    smart00410
    Location:385
    IG_like; Immunoglobulin like
    cd05090
    Location:404686
    PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
    pfam07714
    Location:410683
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_011541526.1XP_011539828.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

    See identical proteins and their annotated locations for XP_011539828.1

    Related
    ENSP00000441637.2, ENST00000545203.2
    Conserved Domains (6) summary
    cd00096
    Location:1280
    Ig; Immunoglobulin domain
    cd07467
    Location:103244
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:248330
    KR; Kringle domain
    smart00410
    Location:385
    IG_like; Immunoglobulin like
    cd05090
    Location:404686
    PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
    pfam07714
    Location:410683
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_017001376.1XP_016856865.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

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