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NRGN neurogranin [ Homo sapiens (human) ]

Gene ID: 4900, updated on 2-Nov-2024

Summary

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Official Symbol
NRGNprovided by HGNC
Official Full Name
neurograninprovided by HGNC
Primary source
HGNC:HGNC:8000
See related
Ensembl:ENSG00000154146 MIM:602350; AllianceGenome:HGNC:8000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RC3; hng
Summary
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 309.5) and lung (RPKM 24.9) See more
Orthologs
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Genomic context

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See NRGN in Genome Data Viewer
Location:
11q24.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124739942..124747210)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124768605..124775873)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124609838..124617106)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sialic acid acetylesterase Neighboring gene uncharacterized LOC124902780 Neighboring gene sperm autoantigenic protein 17 Neighboring gene MPRA-validated peak1498 silencer Neighboring gene uncharacterized LOC107984405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124615273-124615806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124616341-124616874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:124621349-124621910 Neighboring gene Sharpr-MPRA regulatory region 10895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5691 Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124631741-124632244 Neighboring gene ESAM antisense RNA 1 Neighboring gene endothelial cell adhesion molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic and functional analysis of the gene encoding neurogranin in schizophrenia. Shen YC, et al. Schizophr Res, 2012 May. PMID 22306195
  2. Minor allele C of rs12807809 polymorphism in NRGN contributes to the severity of psychosis in patients with Schizophrenia in South Indian population. Sudesh R, et al. Neurosci Lett, 2017 May 10. PMID 28389239
  3. Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease. Tarawneh R, et al. JAMA Neurol, 2016 May 1. PMID 27018940, Free PMC Article
  4. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. Wen Z, et al. J Affect Disord, 2016 Apr. PMID 26828755
  5. Increased CSF neurogranin concentration is specific to Alzheimer disease. Wellington H, et al. Neurology, 2016 Mar 1. PMID 26826204, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CSF neurogranin levels as a biomarker in Alzheimer's disease and frontotemporal lobar degeneration: a cross-sectional analysis.
    Title: CSF neurogranin levels as a biomarker in Alzheimer's disease and frontotemporal lobar degeneration: a cross-sectional analysis.
  2. Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells.
    Title: Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells.
  3. The diagnostic and prognostic value of serum neurogranin in acute ischemic stroke.
    Title: The diagnostic and prognostic value of serum neurogranin in acute ischemic stroke.
  4. Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer's disease.
    Title: Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer's disease.
  5. Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients.
    Title: Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients.
  6. Neurogranin as a Novel Biomarker in Alzheimer's Disease.
    Title: Neurogranin as a Novel Biomarker in Alzheimer's Disease.
  7. Interrelations of Alzheimer s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation.
    Title: Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation.
  8. The role of synaptic biomarkers in the spectrum of neurodegenerative diseases.
    Title: The role of synaptic biomarkers in the spectrum of neurodegenerative diseases.
  9. Molecular forms of neurogranin in cerebrospinal fluid.
    Title: Molecular forms of neurogranin in cerebrospinal fluid.
  10. Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders.
    Title: Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Common variants conferring risk of schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
neurogranin
Names
calmodulin-binding protein
neurogranin (protein kinase C substrate, RC3)
protein kinase C substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126181.2 → NP_001119653.1  neurogranin

    See identical proteins and their annotated locations for NP_001119653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice acceptor site in a 3'UTR exon.
    Source sequence(s)
    AP000866, BC002835, BM923818, DB474181
    Consensus CDS
    CCDS8451.1
    UniProtKB/Swiss-Prot
    Q92686
    Related
    ENSP00000399591.1, ENST00000412681.2
    Conserved Domains (1) summary
    smart00015
    Location:32 → 47
    IQ; Calmodulin-binding motif

  2. NM_006176.3 → NP_006167.1  neurogranin

    See identical proteins and their annotated locations for NP_006167.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice acceptor site in a 3'UTR exon.
    Source sequence(s)
    AP000866, BC002835, DB474181, Y09689
    Consensus CDS
    CCDS8451.1
    UniProtKB/Swiss-Prot
    Q92686
    Related
    ENSP00000284292.5, ENST00000284292.11
    Conserved Domains (1) summary
    smart00015
    Location:32 → 47
    IQ; Calmodulin-binding motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    124739942..124747210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    124768605..124775873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92686.1 GenPept UniProtKB/Swiss-Prot:Q92686

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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