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NRGN neurogranin [ Homo sapiens (human) ]

Gene ID: 4900, updated on 17-Jun-2024

Summary

Official Symbol
NRGNprovided by HGNC
Official Full Name
neurograninprovided by HGNC
Primary source
HGNC:HGNC:8000
See related
Ensembl:ENSG00000154146 MIM:602350; AllianceGenome:HGNC:8000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RC3; hng
Summary
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 309.5) and lung (RPKM 24.9) See more
Orthologs
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Genomic context

See NRGN in Genome Data Viewer
Location:
11q24.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124739942..124747210)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124768605..124775873)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124609838..124617106)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sialic acid acetylesterase Neighboring gene uncharacterized LOC124902780 Neighboring gene sperm autoantigenic protein 17 Neighboring gene MPRA-validated peak1498 silencer Neighboring gene uncharacterized LOC107984405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124615273-124615806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124616341-124616874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:124621349-124621910 Neighboring gene Sharpr-MPRA regulatory region 10895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5691 Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124631741-124632244 Neighboring gene ESAM antisense RNA 1 Neighboring gene endothelial cell adhesion molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Common variants conferring risk of schizophrenia.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neurogranin
Names
calmodulin-binding protein
neurogranin (protein kinase C substrate, RC3)
protein kinase C substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126181.2NP_001119653.1  neurogranin

    See identical proteins and their annotated locations for NP_001119653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice acceptor site in a 3'UTR exon.
    Source sequence(s)
    AP000866, BC002835, BM923818, DB474181
    Consensus CDS
    CCDS8451.1
    UniProtKB/Swiss-Prot
    Q92686
    Related
    ENSP00000399591.1, ENST00000412681.2
    Conserved Domains (1) summary
    smart00015
    Location:3247
    IQ; Calmodulin-binding motif
  2. NM_006176.3NP_006167.1  neurogranin

    See identical proteins and their annotated locations for NP_006167.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice acceptor site in a 3'UTR exon.
    Source sequence(s)
    AP000866, BC002835, DB474181, Y09689
    Consensus CDS
    CCDS8451.1
    UniProtKB/Swiss-Prot
    Q92686
    Related
    ENSP00000284292.5, ENST00000284292.11
    Conserved Domains (1) summary
    smart00015
    Location:3247
    IQ; Calmodulin-binding motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    124739942..124747210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    124768605..124775873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)