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NPPB natriuretic peptide B [ Homo sapiens (human) ]

Gene ID: 4879, updated on 26-Sep-2021

Summary

Official Symbol
NPPBprovided by HGNC
Official Full Name
natriuretic peptide Bprovided by HGNC
Primary source
HGNC:HGNC:7940
See related
Ensembl:ENSG00000120937 MIM:600295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNP; Iso-ANP
Summary
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis.
Expression
Restricted expression toward heart (RPKM 1334.9) See more
Orthologs
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Genomic context

See NPPB in Genome Data Viewer
Location:
1p36.22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (11857464..11858945, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11917521..11919002, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chloride voltage-gated channel 6 Neighboring gene NPPA antisense RNA 1 Neighboring gene VISTA enhancer hs2123 Neighboring gene natriuretic peptide A Neighboring gene SBF1 pseudogene 2 Neighboring gene VISTA enhancer hs2125

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies eight loci associated with blood pressure.
GeneReviews: Not available
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables diuretic hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity NAS
Non-traceable Author Statement
more info
PubMed 
enables hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in blood vessel diameter maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in body fluid secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac conduction system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of renal sodium excretion TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of urine volume TAS
Traceable Author Statement
more info
PubMed 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood pressure NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of vascular permeability TAS
Traceable Author Statement
more info
PubMed 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
natriuretic peptides B
Names
brain natriuretic factor prohormone
brain type natriuretic peptide
gamma-brain natriuretic peptide
natriuretic peptide precursor B
natriuretic protein
preproBNP
proBNP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002521.3NP_002512.1  natriuretic peptides B preproprotein

    See identical proteins and their annotated locations for NP_002512.1

    Status: REVIEWED

    Source sequence(s)
    AJ708502, AL021155, BC025785, M25296
    Consensus CDS
    CCDS140.1
    UniProtKB/Swiss-Prot
    P16860
    Related
    ENSP00000365651.3, ENST00000376468.4
    Conserved Domains (1) summary
    pfam00212
    Location:98128
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    11857464..11858945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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