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NPPA natriuretic peptide A [ Homo sapiens (human) ]

Gene ID: 4878, updated on 5-Jul-2025
Official Symbol
NPPAprovided by HGNC
Official Full Name
natriuretic peptide Aprovided by HGNC
Primary source
HGNC:HGNC:7939
See related
Ensembl:ENSG00000175206 MIM:108780; AllianceGenome:HGNC:7939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF
Summary
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]
Expression
Restricted expression toward heart (RPKM 12159.5) See more
Orthologs
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See NPPA in Genome Data Viewer
Location:
1p36.22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11845709..11847783, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11389795..11391868, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11905766..11907840, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11847781-11848588 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11851353-11851865 Neighboring gene methylenetetrahydrofolate reductase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11860626-11861224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11862804-11863700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11863701-11864596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 273 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11865893-11866878 Neighboring gene chloride voltage-gated channel 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 178 Neighboring gene VISTA enhancer hs2123 Neighboring gene NPPA antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11919401-11919567 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11927350-11927499 Neighboring gene natriuretic peptide B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11940245-11940745 Neighboring gene SBF1 pseudogene 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
Atrial fibrillation, familial, 6
MedGen: C2677294 OMIM: 612201 GeneReviews: Not available
Compare labs
Atrial standstill 2
MedGen: C3810401 OMIM: 615745 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanylate cyclase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neuropeptide hormone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables neuropeptide receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aortic valve morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac conduction system development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to angiotensin IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of collecting lymphatic vessel constriction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of potassium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of potassium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of atrial cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to 3-methylcholanthrene IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to muscle stretch TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within sodium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic signaling via neuropeptide IEA
Inferred from Electronic Annotation
more info
 
involved_in system process IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in brush border IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
is_active_in glycinergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in mast cell granule IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
natriuretic peptides A
Names
atrial natriuretic factor prohormone
atrial natriuretic peptide prohormone
atriopeptigen
atriopeptin
cardiodilatin-related peptide
cardionatrin
natriuretic peptide precursor A
preproANP
preproCDD-ANF
prepronatriodilatin
proANF
proANP

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012926.1 RefSeqGene

    Range
    5001..7075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_751

mRNA and Protein(s)

  1. NM_006172.4NP_006163.1  natriuretic peptides A preproprotein

    See identical proteins and their annotated locations for NP_006163.1

    Status: REVIEWED

    Source sequence(s)
    AA779538, BC005893
    Consensus CDS
    CCDS139.1
    UniProtKB/Swiss-Prot
    P01160, Q13766, Q5JZE1
    Related
    ENSP00000365663.3, ENST00000376480.7
    Conserved Domains (1) summary
    smart00183
    Location:123146
    NAT_PEP; Natriuretic peptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11845709..11847783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    11389795..11391868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)