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ATP1B2 ATPase Na+/K+ transporting subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 482, updated on 24-Nov-2020

Summary

Official Symbol
ATP1B2provided by HGNC
Official Full Name
ATPase Na+/K+ transporting subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:805
See related
Ensembl:ENSG00000129244 MIM:182331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMOG
Summary
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Biased expression in brain (RPKM 120.9) and ovary (RPKM 11.3) See more
Orthologs

Genomic context

See ATP1B2 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7646627..7657770)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7554254..7561089)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-undetermined (NNN) 6-1 Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene tumor protein p53 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ephrin B3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
GeneReviews: Not available
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to sodium:potassium-exchanging ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell communication by electrical coupling involved in cardiac conduction TAS
Traceable Author Statement
more info
PubMed 
cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular potassium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular sodium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
lateral ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
membrane repolarization IDA
Inferred from Direct Assay
more info
PubMed 
motor behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
photoreceptor cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane bounded cell projection organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of potassium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sodium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
retina homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
third ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
 
transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte end-foot ISS
Inferred from Sequence or Structural Similarity
more info
 
astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte projection ISS
Inferred from Sequence or Structural Similarity
more info
 
cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell projection membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron to neuron synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
photoreceptor inner segment ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:potassium-exchanging ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
sodium:potassium-exchanging ATPase complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-2
Names
ATPase, Na+/K+ transporting, beta 2 polypeptide
Na, K-ATPase beta-2 polypeptide
adhesion molecule in glia
adhesion molecule on glia
sodium pump subunit beta-2
sodium-potassium ATPase subunit beta 2 (non-catalytic)
sodium/potassium-dependent ATPase beta-2 subunit
sodium/potassium-dependent ATPase subunit beta-2
sodium/potassium-transporting ATPase beta-2 chain
NP_001290192.1
NP_001669.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303263.2NP_001290192.1  sodium/potassium-transporting ATPase subunit beta-2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an upstream exon in place of the first two exons and initiates translation at a downstream site compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC007421, AK290143, AL120033, DA199365
    UniProtKB/Swiss-Prot
    P14415
    Conserved Domains (1) summary
    cl08255
    Location:1207
    Na_K-ATPase; Sodium / potassium ATPase beta chain
  2. NM_001678.5NP_001669.3  sodium/potassium-transporting ATPase subunit beta-2 isoform 1

    See identical proteins and their annotated locations for NP_001669.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007421, AK290143, AL120033, DA122526
    Consensus CDS
    CCDS32550.1
    UniProtKB/Swiss-Prot
    P14415
    Related
    ENSP00000250111.4, ENST00000250111.9
    Conserved Domains (1) summary
    TIGR01107
    Location:2289
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7646627..7657770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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