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NKG7 natural killer cell granule protein 7 [ Homo sapiens (human) ]

Gene ID: 4818, updated on 22-Sep-2022

Summary

Official Symbol
NKG7provided by HGNC
Official Full Name
natural killer cell granule protein 7provided by HGNC
Primary source
HGNC:HGNC:7830
See related
Ensembl:ENSG00000105374 MIM:606008; AllianceGenome:HGNC:7830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG1; GMP-17; p15-TIA-1
Summary
Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 170.3), spleen (RPKM 54.6) and 5 other tissues See more
Orthologs
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Genomic context

See NKG7 in Genome Data Viewer
Location:
19q13.41
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51371620..51372654, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54460261..54461295, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51874874..51875908, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein subunit beta Neighboring gene claudin domain containing 2 Neighboring gene uncharacterized LOC124904752 Neighboring gene lens intrinsic membrane protein 2 Neighboring gene LIM2 and SIGLEC10 antisense RNA 1 Neighboring gene chromosome 19 open reading frame 84

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cytolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to protozoan IDA
Inferred from Direct Assay
more info
PubMed 
involved_in granzyme-mediated programmed cell death signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in natural killer cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in natural killer cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in natural killer cell mediated cytotoxicity directed against tumor cell target ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytolytic granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytolytic granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein NKG7
Names
G-CSF-induced gene 1 protein
GIG-1 protein
granule membrane protein 17
granule membrane protein of 17 kDa
natural killer cell group 7 sequence
natural killer cell protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363693.2NP_001350622.1  protein NKG7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI313472, BG743982, S69115
    Consensus CDS
    CCDS86796.1
    UniProtKB/TrEMBL
    A0A0B4J2A6
    Related
    ENSP00000468910.1, ENST00000595217.1
  2. NM_005601.4NP_005592.1  protein NKG7 isoform 1

    See identical proteins and their annotated locations for NP_005592.1

    Status: VALIDATED

    Source sequence(s)
    AI313472, S69115
    Consensus CDS
    CCDS12830.1
    UniProtKB/Swiss-Prot
    Q16617
    Related
    ENSP00000221978.4, ENST00000221978.10
    Conserved Domains (1) summary
    cl21598
    Location:21149
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51371620..51372654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723228.4XP_006723291.1  protein NKG7 isoform X2

    Conserved Domains (1) summary
    cl21598
    Location:50100
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. XM_005258955.4XP_005259012.1  protein NKG7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54460261..54461295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)