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NKG7 natural killer cell granule protein 7 [ Homo sapiens (human) ]

Gene ID: 4818, updated on 13-Mar-2020

Summary

Official Symbol
NKG7provided by HGNC
Official Full Name
natural killer cell granule protein 7provided by HGNC
Primary source
HGNC:HGNC:7830
See related
Ensembl:ENSG00000105374 MIM:606008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG1; GMP-17; p15-TIA-1
Expression
Biased expression in bone marrow (RPKM 170.3), spleen (RPKM 54.6) and 5 other tissues See more
Orthologs

Genomic context

See NKG7 in Genome Data Viewer
Location:
19q13.41
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51371616..51372688, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51874874..51875976, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein subunit beta Neighboring gene claudin domain containing 2 Neighboring gene uncharacterized LOC105372446 Neighboring gene lens intrinsic membrane protein 2 Neighboring gene chromosome 19 open reading frame 84

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein NKG7
Names
G-CSF-induced gene 1 protein
GIG-1 protein
granule membrane protein 17
granule membrane protein of 17 kDa
natural killer cell group 7 sequence
natural killer cell protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363693.2NP_001350622.1  protein NKG7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI313472, BG743982, S69115
    Consensus CDS
    CCDS86796.1
    Related
    ENSP00000468910.1, ENST00000595217.1
  2. NM_005601.4NP_005592.1  protein NKG7 isoform 1

    See identical proteins and their annotated locations for NP_005592.1

    Status: VALIDATED

    Source sequence(s)
    AI313472, S69115
    Consensus CDS
    CCDS12830.1
    UniProtKB/Swiss-Prot
    Q16617
    Related
    ENSP00000221978.4, ENST00000221978.10
    Conserved Domains (1) summary
    cl21598
    Location:21149
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51371616..51372688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723228.3XP_006723291.1  protein NKG7 isoform X3

    Conserved Domains (1) summary
    cl21598
    Location:50100
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. XM_005258955.3XP_005259012.1  protein NKG7 isoform X2

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