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ATOH1 atonal bHLH transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 474, updated on 25-Nov-2021

Summary

Official Symbol
ATOH1provided by HGNC
Official Full Name
atonal bHLH transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:797
See related
Ensembl:ENSG00000172238 MIM:601461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATH1; HATH1; MATH-1; bHLHa14
Summary
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See ATOH1 in Genome Data Viewer
Location:
4q22.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (93828753..93830964)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (94749904..94752115)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor delta type subunit 2 Neighboring gene uncharacterized LOC107986295 Neighboring gene RNA, 5S ribosomal pseudogene 164 Neighboring gene SMARCAD1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 519 Neighboring gene high mobility group box 3 pseudogene 15

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in auditory receptor cell fate determination IEA
Inferred from Electronic Annotation
more info
 
involved_in auditory receptor cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gliogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inner ear auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein atonal homolog 1
Names
atonal homolog 1
atonal homolog bHLH transcription factor 1
basic helix-loop-helix family member a14
class A basic helix-loop-helix protein 14
helix-loop-helix protein hATH-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005172.2NP_005163.1  protein atonal homolog 1

    See identical proteins and their annotated locations for NP_005163.1

    Status: REVIEWED

    Source sequence(s)
    AC087413, BC113625
    Consensus CDS
    CCDS3638.1
    UniProtKB/Swiss-Prot
    Q92858
    Related
    ENSP00000302216.4, ENST00000306011.6
    Conserved Domains (1) summary
    cd00083
    Location:158216
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    93828753..93830964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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