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NDUFB2 NADH:ubiquinone oxidoreductase subunit B2 [ Homo sapiens (human) ]

Gene ID: 4708, updated on 21-Dec-2019

Summary

Official Symbol
NDUFB2provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit B2provided by HGNC
Primary source
HGNC:HGNC:7697
See related
Ensembl:ENSG00000090266 MIM:603838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGGG; CI-AGGG
Summary
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 93.9), kidney (RPKM 78.0) and 25 other tissues See more
Orthologs

Genomic context

See NDUFB2 in Genome Data Viewer
Location:
7q34
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (140696708..140706643)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140396481..140406446)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986718 Neighboring gene NDUFB2 antisense RNA 1 Neighboring gene aarF domain containing kinase 2 Neighboring gene B-Raf proto-oncogene, serine/threonine kinase Neighboring gene RNA, U6 small nuclear 85, pseudogene Neighboring gene uncharacterized LOC105375536 Neighboring gene uncharacterized LOC107986720

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex I NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NADH-ubiquinone oxidoreductase AGGG subunit
complex I AGGG subunit
complex I-AGGG
NP_004537.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004546.3NP_004537.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_004537.1

    Status: REVIEWED

    Source sequence(s)
    AF067166
    Consensus CDS
    CCDS5862.1
    UniProtKB/Swiss-Prot
    O95178
    UniProtKB/TrEMBL
    A4D1T5
    Related
    ENSP00000247866.4, ENST00000247866.9
    Conserved Domains (1) summary
    pfam14813
    Location:37104
    NADH_B2; NADH dehydrogenase 1 beta subcomplex subunit 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    140696708..140706643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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