MYOG myogenin [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYOGprovided by HGNC
Official Full Name: myogeninprovided by HGNC
Primary source: HGNC:HGNC:7612
See related: Ensembl:ENSG00000122180 MIM:159980; Vega:OTTHUMG00000042127
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MYF4; myf-4; bHLHc3
Summary: Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
Expression: Biased expression in prostate (RPKM 2.6) and esophagus (RPKM 0.9) See more
Orthologs: mouse all

Genomic context

Location:: 1q32.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	1	NC_000001.11 (203083129..203086038, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (203052257..203055166, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin.
Title: AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin.
results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle
Title: Myogenin is a positive regulator of MEGF10 expression in skeletal muscle.
Sustained GSK3beta activity represses a critical regulatory step in the myogenic cascade, contributing to the undifferentiated, proliferative phenotype in alveolar rhabdomyosarcoma.
Title: Glycogen synthase kinase 3β represses MYOGENIN function in alveolar rhabdomyosarcoma.
Our study illustrates that focal myogenin immunoreactivity occurs uncommonly in fibroepithelial polyps of the lower female genital tract.
Title: Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls.
Data indicate that muscle MYOG mRNA expression doubled, whereas MSTN protein expression decreased following immobilization.
Title: Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content.
SREBP-1 regulate muscle protein synthesis through the downregulation of the expression of MYOD1, MYOG and MEF2C factors.
Title: SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.
the FACT complex promotes myogenin-dependent transcription
Title: Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes.
Human muscle samples were analysed at different time-points post-denervation to evaluate changes in myogenin expression and their relationship with skeletal muscle atrophy.
Title: The study of myogenin expression in denervated human skeletal muscles.
After 2 years of denervation, expression of myogenin protein in myonuclei was decreased, but after 3 years of denervation, no expression of myogenin protein in myonuclei was found in denervated posterior cricoarytenoid muscles.
Title: [Correlation between myogenin and transforming growth factor-beta1 expression in long-term human denervated posterior cricoarytenoid muscles].
The physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under Tetradecanoylphorbol Acetate -induced differentiation.
Title: CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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CDO in myogenesis, organism-specific biosystem (from REACTOME)
CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
Hypertrophy Model, organism-specific biosystem (from WikiPathways)
Hypertrophy Model, organism-specific biosystem
Hypertrophy Model
Myogenesis, organism-specific biosystem (from REACTOME)
Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
Regulation of Wnt-mediated beta catenin signaling and target gene transcription

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G15880 (e-PCR)
- UniSTS:24835

SHGC-11939 (e-PCR)
- UniSTS:20748

STS-X17651 (e-PCR)
- UniSTS:62224

MYOG_8492 (e-PCR)
- UniSTS:467789

Homology

Homologs of the MYOG gene: The MYOG gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 228 organisms have orthologs with human gene MYOG
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription activator activity, RNA polymerase II-specific	TAS Traceable Author Statement more info	PubMed
DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISM Inferred from Sequence Model more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	NAS Non-traceable Author Statement more info	PubMed
E-box binding	ISS Inferred from Sequence or Structural Similarity more info
RNA polymerase II proximal promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA polymerase II regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cellular response to estradiol stimulus	ISS Inferred from Sequence or Structural Similarity more info
cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
cellular response to lithium ion	IEA Inferred from Electronic Annotation more info
cellular response to magnetism	IEA Inferred from Electronic Annotation more info
cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
mRNA transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
muscle cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
myoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
ossification	IEA Inferred from Electronic Annotation more info
positive regulation of cell cycle arrest	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of muscle atrophy	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of muscle cell differentiation	TAS Traceable Author Statement more info
positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of skeletal muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
regulation of skeletal muscle satellite cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
response to denervation involved in regulation of muscle adaptation	ISS Inferred from Sequence or Structural Similarity more info
response to electrical stimulus involved in regulation of muscle adaptation	ISS Inferred from Sequence or Structural Similarity more info
response to gravity	IEA Inferred from Electronic Annotation more info
response to muscle activity involved in regulation of muscle adaptation	ISS Inferred from Sequence or Structural Similarity more info
skeletal muscle atrophy	IEA Inferred from Electronic Annotation more info
skeletal muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
skeletal muscle tissue development	TAS Traceable Author Statement more info	PubMed
skeletal muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
striated muscle atrophy	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info
protein-DNA complex	ISS Inferred from Sequence or Structural Similarity more info
transcription factor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: myogenin

Names: class C basic helix-loop-helix protein 3; myogenic factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.