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MYOG myogenin [ Homo sapiens (human) ]

Gene ID: 4656, updated on 7-Oct-2018

Summary

Official Symbol
MYOGprovided by HGNC
Official Full Name
myogeninprovided by HGNC
Primary source
HGNC:HGNC:7612
See related
Ensembl:ENSG00000122180 MIM:159980; Vega:OTTHUMG00000042127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYF4; myf-4; bHLHc3
Summary
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 2.6) and esophagus (RPKM 0.9) See more
Orthologs

Genomic context

See MYOG in Genome Data Viewer
Location:
1q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (203083129..203086038, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203052257..203055166, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 183A Neighboring gene PTPRF interacting protein alpha 4 Neighboring gene uncharacterized LOC105371687 Neighboring gene adenosine A1 receptor Neighboring gene myosin binding protein H

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to magnetism IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
muscle cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of muscle atrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of myoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of skeletal muscle satellite cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to denervation involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to electrical stimulus involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to gravity IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle atrophy IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
striated muscle atrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-DNA complex ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myogenin
Names
class C basic helix-loop-helix protein 3
myogenic factor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002479.5NP_002470.2  myogenin

    See identical proteins and their annotated locations for NP_002470.2

    Status: VALIDATED

    Source sequence(s)
    AC105940, BC053899
    Consensus CDS
    CCDS1433.1
    UniProtKB/Swiss-Prot
    P15173
    Related
    ENSP00000241651.4, OTTHUMP00000039094, ENST00000241651.4, OTTHUMT00000100279
    Conserved Domains (2) summary
    smart00520
    Location:186
    BASIC; Basic domain in HLH proteins of MYOD family
    pfam00010
    Location:82133
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    203083129..203086038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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