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HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 459844, updated on 17-Aug-2024

Summary

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Official Symbol
HECW2provided by VGNC
Official Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by VGNC
Primary source
VGNC:VGNC:1959
Locus tag
CK820_G0014739
See related
Ensembl:ENSPTRG00000012764
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 13 NC_072411.2 (98207042..98595428, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (98179002..98594438, complement)

Chromosome 13 - NC_072411.2Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 7 Neighboring gene glutathione S-transferase A4-like Neighboring gene uncharacterized LOC112208390 Neighboring gene small nucleolar RNA U13 Neighboring gene serine/threonine kinase 17b Neighboring gene uncharacterized LOC134808060 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene coiled-coil domain containing 150 Neighboring gene general transcription factor IIIC subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECW2
XP_009442182.1
XP_063647478.1
XP_063647479.1
XP_063647480.1
XP_063647481.1
XP_063647482.1
XP_063647483.1
XP_063647484.1
XP_063647486.1
XP_063647487.1
XP_063647488.1
XP_063647489.1
XP_063647490.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    98207042..98595428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063791409.1 → XP_063647479.1  E3 ubiquitin-protein ligase HECW2 isoform X1

    UniProtKB/TrEMBL
    A0A2I3TLA3

  2. XM_063791410.1 → XP_063647480.1  E3 ubiquitin-protein ligase HECW2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3TLA3, A0A2J8N4L9, A0A6D2W551, H2QJ66

  3. XM_063791408.1 → XP_063647478.1  E3 ubiquitin-protein ligase HECW2 isoform X1

    UniProtKB/TrEMBL
    A0A2I3TLA3

  4. XM_009443907.5 → XP_009442182.1  E3 ubiquitin-protein ligase HECW2 isoform X1

    See identical proteins and their annotated locations for XP_009442182.1

    UniProtKB/TrEMBL
    A0A2I3TLA3
    Conserved Domains (6) summary
    cd08691
    Location:185 → 321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00119
    Location:1247 → 1576
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1223 → 1577
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:816 → 845
    WW; WW domain
    pfam12429
    Location:508 → 651
    DUF3676; Protein of unknown function (DUF3676)
    pfam16562
    Location:45 → 164
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

  5. XM_063791411.1 → XP_063647481.1  E3 ubiquitin-protein ligase HECW2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3TLA3, A0A2J8N4L9, A0A6D2W551, H2QJ66

  6. XM_063791417.1 → XP_063647487.1  E3 ubiquitin-protein ligase HECW2 isoform X5

    UniProtKB/TrEMBL
    A0A2I3TLA3

  7. XM_063791413.1 → XP_063647483.1  E3 ubiquitin-protein ligase HECW2 isoform X4

    UniProtKB/TrEMBL
    A0A2I3TLA3

  8. XM_063791420.1 → XP_063647490.1  E3 ubiquitin-protein ligase HECW2 isoform X6

    UniProtKB/TrEMBL
    A0A2J8N4L5

  9. XM_063791419.1 → XP_063647489.1  E3 ubiquitin-protein ligase HECW2 isoform X5

    UniProtKB/TrEMBL
    A0A2I3TLA3

  10. XM_063791416.1 → XP_063647486.1  E3 ubiquitin-protein ligase HECW2 isoform X4

    UniProtKB/TrEMBL
    A0A2I3TLA3

  11. XM_063791412.1 → XP_063647482.1  E3 ubiquitin-protein ligase HECW2 isoform X3

    UniProtKB/TrEMBL
    A0A2I3TLA3

  12. XM_063791418.1 → XP_063647488.1  E3 ubiquitin-protein ligase HECW2 isoform X5

    UniProtKB/TrEMBL
    A0A2I3TLA3

  13. XM_063791414.1 → XP_063647484.1  E3 ubiquitin-protein ligase HECW2 isoform X4

    UniProtKB/TrEMBL
    A0A2I3TLA3

RNA

  1. XR_010150180.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials