U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ValRS Valyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45783, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ValRSprovided by FlyBase
Official Full Name
Valyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027079
Locus tag
Dmel_CG4062
See related
AllianceGenome:FB:FBgn0027079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aaRS(Val); aats-val; Aats-val; BEST:LD45671; CG4062; Dmel\CG4062; dVARS; l(2)03531; l(2)rI255; ld45671; VARS; VRS
Summary
Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; and organism. Orthologous to human VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
49F7-49F7; 2-68 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13198850..13202709)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9086355..9090214)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lysine demethylase 4B Neighboring gene sequoia Neighboring gene uncharacterized protein Neighboring gene Origin recognition complex subunit 3 Neighboring gene FLICE-associated huge protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
  2. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
  3. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. Huang Y, et al. PLoS One, 2015. PMID 26659849, Free PMC Article
  4. Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Li S, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958650, Free PMC Article
  5. MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure. Wu Z, et al. Mol Cell, 2019 Aug 22. PMID 31378462, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables valine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables valine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables valine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in valyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in valyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Valyl-tRNA synthetase
Names
CG4062-PA
CG4062-PB
CG4062-PC
ValRS-PA
ValRS-PB
ValRS-PC
NP_001260946.1
NP_524838.1
NP_725259.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13198850..13202709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274017.1 → NP_001260946.1  Valyl-tRNA synthetase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260946.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF06, T2GFI6
    Conserved Domains (5) summary
    cd07962
    Location:736 → 873
    Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
    cd00817
    Location:129 → 736
    ValRS_core; catalytic core domain of valyl-tRNA synthetases
    PTZ00419
    Location:80 → 1053
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    pfam10458
    Location:978 → 1053
    Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
    pfam13603
    Location:307 → 436
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2

  2. NM_165970.2 → NP_725259.1  Valyl-tRNA synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725259.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E993, T2GFI6
    Related
    FBpp0086847
    Conserved Domains (5) summary
    cd07962
    Location:730 → 867
    Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
    cd00817
    Location:129 → 730
    ValRS_core; catalytic core domain of valyl-tRNA synthetases
    PTZ00419
    Location:80 → 1047
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    pfam10458
    Location:972 → 1047
    Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
    pfam13603
    Location:307 → 436
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2

  3. NM_080099.3 → NP_524838.1  Valyl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E993, T2GFI6
    Related
    FBpp0086848
    Conserved Domains (5) summary
    cd07962
    Location:730 → 867
    Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
    cd00817
    Location:129 → 730
    ValRS_core; catalytic core domain of valyl-tRNA synthetases
    PTZ00419
    Location:80 → 1047
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    pfam10458
    Location:972 → 1047
    Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
    pfam13603
    Location:307 → 436
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF06 A0A0B4KF06
Q0E993 Q0E993
Q960E6 Q960E6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools