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Cyp4p1 Cytochrome P450 4p1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45524, updated on 11-Sep-2024

Summary

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Official Symbol
Cyp4p1provided by FlyBase
Official Full Name
Cytochrome P450 4p1provided by FlyBase
Primary source
FLYBASE:FBgn0015037
Locus tag
Dmel_CG10842
See related
AllianceGenome:FB:FBgn0015037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4p1; anon-WO0140519.35; CG10842; Cyp4P1; CYP4p1; CYP4P1; Dmel\CG10842; P-450; P450
Summary
Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Is expressed in adult head; embryonic/larval Malpighian tubule; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
45B7-45B7; 2-60 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9240041..9242139)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5127546..5129644)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44451 Neighboring gene hikaru genki Neighboring gene Cytochrome P450 4p2 Neighboring gene Cytochrome P450 4p3 Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene Protein kinase N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytochrome P450s Cyp4p1 and Cyp4p2 associated with the DDT tolerance in the Drosophila melanogaster strain 91-R. Seong KM, et al. Pestic Biochem Physiol, 2019 Sep. PMID 31400775
  2. Interactions between detoxification mechanisms and excretion in Malpighian tubules of Drosophila melanogaster. Chahine S, et al. J Exp Biol, 2011 Feb 1. PMID 21228205
  3. Identification and characterization of CYPs induced in the Drosophila antenna by exposure to a plant odorant. Baldwin SR, et al. Sci Rep, 2021 Oct 15. PMID 34654888, Free PMC Article
  4. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
  5. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh DP, et al. Experientia, 1992 Jan 15. PMID 1737575

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4p1
Names
CG10842-PA
Cyp4p1-PA
cytochrome P450
cytochrome P450-4p1
NP_524828.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9240041..9242139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080089.3 → NP_524828.1  cytochrome P450 4p1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524828.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24125, Q9V558
    Related
    FBpp0087673
    Conserved Domains (1) summary
    pfam00067
    Location:54 → 509
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V558.1 Q9V558

Gene LinkOut

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