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folB dihydroneopterin aldolase [ Mycobacterium canettii CIPT 140010059 ]

Gene ID: 45427593, updated on 1-Aug-2024

Summary

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Gene symbol
folB
Gene description
dihydroneopterin aldolase
Locus tag
MCAN_RS18995
Gene type
protein coding
Organism
Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
Lineage
Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Old locus tag
MCAN_36191
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Genomic context

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Sequence:
NC_015848.1 (4101561..4101962, complement)

NC_015848.1Genomic Context describing neighboring genes Neighboring gene DUF6779 domain-containing protein Neighboring gene DUF3180 domain-containing protein Neighboring gene 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase Neighboring gene dihydropteroate synthase Neighboring gene GTP cyclohydrolase I FolE Neighboring gene ATP-dependent zinc metalloprotease FtsH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_015848.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase. Haussmann C, et al. J Biol Chem, 1998 Jul 10. PMID 9651328
  2. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Supply P, et al. Nat Genet, 2013 Feb. PMID 23291586, Free PMC Article
  3. The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex. Bentley SD, et al. PLoS Negl Trop Dis, 2012. PMID 22389744, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General protein information

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Preferred Names
dihydroneopterin aldolase
WP_003419537.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_015848.1 Reference assembly

    Range
    4101561..4101962 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_003419537.1 MULTISPECIES: dihydroneopterin aldolase [Mycobacterium]

    See identical proteins and their annotated locations for WP_003419537.1

    UniProtKB/Swiss-Prot
    A0A1R3Y685, L0TG79, O06275, P0A580, P0A581, P9WNC4, P9WNC5, X2BP64
    UniProtKB/TrEMBL
    A0A045KE67, A0A0H3LF86, A0A0H3MBK3, A0A679LLN5, A0A7W0AN52, A0A829C6C1, A0A9P2M2H2, A0AAE8WN42, A5U8T2, R4M7M8, R4MBJ5
    Conserved Domains (1) summary
    cd00534
    Location:2 → 115
    DHNA_DHNTPE; Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and ...
Nucleotide Protein
Heading Accession and Version

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