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kasA 3-oxoacyl-ACP synthase KasA [ Mycobacterium canettii CIPT 140010059 ]

Gene ID: 45426225, updated on 1-Aug-2024

Summary

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Gene symbol
kasA
Gene description
3-oxoacyl-ACP synthase KasA
Locus tag
MCAN_RS11890
Gene type
protein coding
Organism
Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
Lineage
Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Old locus tag
MCAN_22671
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Genomic context

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Sequence:
NC_015848.1 (2570959..2572209)

NC_015848.1Genomic Context describing neighboring genes Neighboring gene PucR family transcriptional regulator Neighboring gene malonyl CoA-acyl carrier protein transacylase Neighboring gene meromycolate extension acyl carrier protein AcpM Neighboring gene 3-oxoacyl-ACP synthase KasB Neighboring gene acyl-CoA carboxylase subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_015848.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin. Luckner SR, et al. Structure, 2009 Jul 15. PMID 19604480, Free PMC Article
  2. Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis. Bhatt A, et al. J Bacteriol, 2005 Nov. PMID 16267284, Free PMC Article
  3. The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis. Slayden RA, et al. Tuberculosis (Edinb), 2002. PMID 12464486
  4. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Supply P, et al. Nat Genet, 2013 Feb. PMID 23291586, Free PMC Article
  5. The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex. Bentley SD, et al. PLoS Negl Trop Dis, 2012. PMID 22389744, Free PMC Article

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
3-oxoacyl-ACP synthase KasA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_015848.1 Reference assembly

    Range
    2570959..2572209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_003411571.1 MULTISPECIES: 3-oxoacyl-ACP synthase KasA [Mycobacterium]

    See identical proteins and their annotated locations for WP_003411571.1

    UniProtKB/Swiss-Prot
    A0A1R3Y0P3, H8ESN0, L0T991, P63454, P63455, P9WQD8, P9WQD9, Q10524, X2BKI6
    UniProtKB/TrEMBL
    A0A045JQD6, A0A0H3MF34, A0A679LIB9, A0A7V9W9P0, A0A829C3Q4, A0A9P2H9F6, A0AAE9BCW9, A5U4S7, G7QZC2
    Conserved Domains (1) summary
    cl09938
    Location:1 → 416
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
Nucleotide Protein
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