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net net [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45339, updated on 18-Sep-2024

Summary

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Official Symbol
netprovided by FlyBase
Official Full Name
netprovided by FlyBase
Primary source
FLYBASE:FBgn0002931
Locus tag
Dmel_CG11450
See related
AllianceGenome:FB:FBgn0002931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHc42; CG11450; Dmel\CG11450; Group IId; Net; shout; Shout
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in imaginal disc-derived wing vein specification and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including amnioserosa anlage; dorsal ectoderm; ectoderm anlage; extended germ band embryo; and mesoderm anlage. Orthologous to human ATOH8 (atonal bHLH transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
21B1-21B1; 2-0.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (82421..87387, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (82421..87387, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44987 Neighboring gene galectin Neighboring gene uncharacterized protein Neighboring gene Zizimin-related Neighboring gene Cysteine rich with EGF like domains Neighboring gene Na[+]/H[+] hydrogen exchanger 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased type IV collagenase in lgl-induced invasive tumors of Drosophila. Woodhouse E, et al. Cell Growth Differ, 1994 Feb. PMID 8180128
  2. The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells. Hatsumi M, et al. J Cell Sci, 1992 Dec. PMID 1487485
  3. Hereditary suppression of lethal (2) giant larvae malignant tumor development in Drosophila by gene transfer. Opper M, et al. Oncogene, 1987 May. PMID 2830580
  4. Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system. Akin O, et al. Elife, 2016 Oct 15. PMID 27743477, Free PMC Article
  5. Genetic determinants of glutamine synthetase in Drosophila melanogaster: a gene for glutamine synthetase I resides in the 21B3-6 region. Caggese C, et al. Biochem Genet, 1988 Oct. PMID 2907404

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in imaginal disc-derived wing vein morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
net
Names
CG11450-PB
CG11450-PC
net-PB
net-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    82421..87387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080081.3 → NP_524820.2  net, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524820.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KH24, Q9BMU0, Q9VPI8
    Conserved Domains (1) summary
    pfam00010
    Location:269 → 320
    HLH; Helix-loop-helix DNA-binding domain

  2. NM_001272860.1 → NP_001259789.1  net, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259789.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KH24, Q9BMU0, Q9VPI8
    Conserved Domains (1) summary
    pfam00010
    Location:269 → 320
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KH24 Q7KH24
Q9VPI8 Q9VPI8

Gene LinkOut

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