NR1H4 nuclear receptor subfamily 1 group H member 4 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: NR1H4provided by VGNC
Official Full Name: nuclear receptor subfamily 1 group H member 4provided by VGNC
Primary source: VGNC:VGNC:5505
Locus tag: CK820_G0016127
See related: Ensembl:ENSPTRG00000005345
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	10	NC_072408.2 (107299739..107390130)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	12	NC_072410.1 (105919557..106010035)

Chromosome 10 - NC_072408.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

G64580 (e-PCR)
- UniSTS:163844

RH79063 (e-PCR)
- UniSTS:73504

NR1I2_2318 (e-PCR)
- UniSTS:280873

D12S332 (e-PCR), detects polymorphism
- UniSTS:75347

NoName (e-PCR)
- UniSTS:495214

SHGC-81175 (e-PCR)
- UniSTS:102001

RH15652 (e-PCR)
- UniSTS:63145

D12S871 (e-PCR)
- UniSTS:62137

G64833 (e-PCR)
- UniSTS:164798

PMC219489P1 (e-PCR)
- UniSTS:272083

PMC219489P2 (e-PCR)
- UniSTS:272084

PMC219489P3 (e-PCR)
- UniSTS:272085

AFM326tf5 (e-PCR)
- UniSTS:43736

SGC33913 (e-PCR)
- UniSTS:18145

PMC137182P6 (e-PCR)
- UniSTS:270827

D12S332 (e-PCR), detects polymorphism
- UniSTS:41461

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables bile acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bile acid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

107299739..107390130

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009426088.4 → XP_009424363.1 bile acid receptor isoform X3

See identical proteins and their annotated locations for XP_009424363.1

UniProtKB/TrEMBL

A0A2I3SDF1, A0A2J8N0A5, A0A2J8N0A8, A0A6D2WWJ2

Related

ENSPTRP00000075060.1

Conserved Domains (2) summary

cd06936
Location:251 → 471

NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors

cd06962
Location:124 → 211

NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers
XM_003952271.6 → XP_003952320.1 bile acid receptor isoform X4

UniProtKB/TrEMBL

A0A2I3SDF1, A0A2J8N0A5, A0A2J8N0B4, A0A6D2WHK3, A0A6D2WWJ2, H2Q6P6

Related

ENSPTRP00000009088.5

Conserved Domains (2) summary

cd06936
Location:247 → 467

NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors

cd06962
Location:124 → 207

NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers
XM_054664614.2 → XP_054520589.1 bile acid receptor isoform X3

UniProtKB/TrEMBL

A0A2I3SDF1, A0A2J8N0A5, A0A2J8N0A8, A0A6D2WWJ2
XM_009426087.5 → XP_009424362.1 bile acid receptor isoform X1

UniProtKB/TrEMBL

A0A2I3S5L3, A0A2I3SDF1, A0A2J8N0A5, A0A2J8N0B1, A0A6D2WFS2, A0A6D2WWJ2

Related

ENSPTRP00000072319.1

Conserved Domains (2) summary

cd06936
Location:261 → 481

NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors

cd06962
Location:134 → 221

NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers
XM_509299.8 → XP_509299.2 bile acid receptor isoform X2

UniProtKB/TrEMBL

A0A2I3SDF1, A0A2J8N0A4, A0A2J8N0A5, A0A6D2WWJ2

Conserved Domains (2) summary

cd06936
Location:257 → 477

NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors

cd06962
Location:134 → 217

NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers