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KPRP keratinocyte proline rich protein [ Homo sapiens (human) ]

Gene ID: 448834, updated on 9-Jun-2025
Official Symbol
KPRPprovided by HGNC
Official Full Name
keratinocyte proline rich proteinprovided by HGNC
Primary source
HGNC:HGNC:31823
See related
Ensembl:ENSG00000203786 MIM:613260; AllianceGenome:HGNC:31823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf45
Summary
This gene encodes a proline-rich skin protein possibly involved in keratinocyte differentiation. [provided by RefSeq, Jul 2016]
Expression
Restricted expression toward skin (RPKM 105.2) See more
Orthologs
NEW
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See KPRP in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152758025..152762056)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151894570..151898601)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152730501..152734532)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene late cornified envelope pseudogene 2 Neighboring gene late cornified envelope pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:152740212-152740401 Neighboring gene late cornified envelope 1F Neighboring gene late cornified envelope 1E

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within desmosome organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epidermis development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of skin barrier IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skin development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
Preferred Names
keratinocyte proline-rich protein
Names
keratinocyte expressed, proline-rich protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051190.1 RefSeqGene

    Range
    4996..9027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025231.3NP_001020402.1  keratinocyte proline-rich protein

    See identical proteins and their annotated locations for NP_001020402.1

    Status: REVIEWED

    Source sequence(s)
    AL353779
    Consensus CDS
    CCDS30862.1
    UniProtKB/Swiss-Prot
    Q5T749
    Related
    ENSP00000475216.1, ENST00000606109.2
    Conserved Domains (1) summary
    PHA03247
    Location:250534
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152758025..152762056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421164.1XP_047277120.1  keratinocyte proline-rich protein isoform X1

    UniProtKB/Swiss-Prot
    Q5T749

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    151894570..151898601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336695.1XP_054192670.1  keratinocyte proline-rich protein isoform X1