U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARHGEF35 Rho guanine nucleotide exchange factor 35 [ Homo sapiens (human) ]

Gene ID: 445328, updated on 26-Oct-2022

Summary

Official Symbol
ARHGEF35provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 35provided by HGNC
Primary source
HGNC:HGNC:33846
See related
Ensembl:ENSG00000213214 AllianceGenome:HGNC:33846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHGEF5L
Expression
Broad expression in thyroid (RPKM 25.8), colon (RPKM 15.5) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ARHGEF35 in Genome Data Viewer
Location:
7q35
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144186083..144195879, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145466560..145476351, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143883176..143892972, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AO member 1 pseudogene Neighboring gene ARHGEF35 antisense RNA 1 Neighboring gene CTAGE family member 4 Neighboring gene olfactory receptor family 2 subfamily A member 42 Neighboring gene OR2A1 antisense RNA 1 Neighboring gene olfactory receptor family 2 subfamily A member 20 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
rho guanine nucleotide exchange factor 35
Names
Rho guanine nucleotide exchange factor (GEF) 35
rho guanine nucleotide exchange factor 5-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003702.3NP_001003702.2  rho guanine nucleotide exchange factor 35

    See identical proteins and their annotated locations for NP_001003702.2

    Status: VALIDATED

    Source sequence(s)
    AC004889
    Consensus CDS
    CCDS34770.1
    UniProtKB/Swiss-Prot
    A5YM69, Q6ZUI2
    Related
    ENSP00000367355.3, ENST00000378115.3
    Conserved Domains (1) summary
    pfam15441
    Location:1478
    ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35
  2. NM_001368318.1NP_001355247.1  rho guanine nucleotide exchange factor 35

    Status: VALIDATED

    Source sequence(s)
    MH721903
    Consensus CDS
    CCDS34770.1
    UniProtKB/Swiss-Prot
    Q6ZUI2
    Related
    ENSP00000510684.1, ENST00000688754.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    144186083..144195879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654715.1 Reference GRCh38.p14 PATCHES

    Range
    140648..150440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    145466560..145476351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)