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MSI1 musashi RNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 4440, updated on 13-Jan-2019

Summary

Official Symbol
MSI1provided by HGNC
Official Full Name
musashi RNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7330
See related
Ensembl:ENSG00000135097 MIM:603328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues See more
Orthologs

Genomic context

See MSI1 in Genome Data Viewer
Location:
12q24.31
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (120339662..120369180, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120779133..120806983, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene phospholipase A2 group IB Neighboring gene ribosomal protein S27 pseudogene 25 Neighboring gene cytochrome c oxidase subunit 6A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nervous system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
polysome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein Musashi homolog 1
Names
musashi-1
musashi1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002442.4NP_002433.1  RNA-binding protein Musashi homolog 1

    See identical proteins and their annotated locations for NP_002433.1

    Status: REVIEWED

    Source sequence(s)
    AB012851, AC003982, AI583233, BX393884
    Consensus CDS
    CCDS9196.1
    UniProtKB/Swiss-Prot
    O43347
    Related
    ENSP00000257552.2, ENST00000257552.6
    Conserved Domains (3) summary
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2296
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    cl25887
    Location:32339
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    120339662..120369180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538361.3XP_011536663.1  RNA-binding protein Musashi homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011536663.1

    UniProtKB/Swiss-Prot
    O43347
    Conserved Domains (3) summary
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2296
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    cl25887
    Location:32339
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. XM_011538363.2XP_011536665.1  RNA-binding protein Musashi homolog 1 isoform X4

    See identical proteins and their annotated locations for XP_011536665.1

    Conserved Domains (3) summary
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2296
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    cl25887
    Location:32329
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  3. XM_011538362.2XP_011536664.1  RNA-binding protein Musashi homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_011536664.1

    Conserved Domains (3) summary
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2296
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    cl25887
    Location:32320
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  4. XM_006719403.3XP_006719466.1  RNA-binding protein Musashi homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006719466.1

    Conserved Domains (3) summary
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2296
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    cl25887
    Location:32328
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  5. XM_011538365.2XP_011536667.1  RNA-binding protein Musashi homolog 1 isoform X6

    See identical proteins and their annotated locations for XP_011536667.1

    Conserved Domains (2) summary
    COG0724
    Location:584
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:780
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  6. XM_011538366.2XP_011536668.1  RNA-binding protein Musashi homolog 1 isoform X6

    See identical proteins and their annotated locations for XP_011536668.1

    Conserved Domains (2) summary
    COG0724
    Location:584
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:780
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  7. XM_011538364.2XP_011536666.1  RNA-binding protein Musashi homolog 1 isoform X5

    Conserved Domains (2) summary
    COG0724
    Location:887
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:1083
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  8. XM_006719404.3XP_006719467.1  RNA-binding protein Musashi homolog 1 isoform X7

    See identical proteins and their annotated locations for XP_006719467.1

    Conserved Domains (2) summary
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:2201
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  9. XM_011538371.2XP_011536673.1  RNA-binding protein Musashi homolog 1 isoform X7

    See identical proteins and their annotated locations for XP_011536673.1

    Conserved Domains (2) summary
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:2201
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  10. XM_011538368.2XP_011536670.1  RNA-binding protein Musashi homolog 1 isoform X7

    See identical proteins and their annotated locations for XP_011536670.1

    Conserved Domains (2) summary
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:2201
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  11. XM_011538370.2XP_011536672.1  RNA-binding protein Musashi homolog 1 isoform X7

    See identical proteins and their annotated locations for XP_011536672.1

    Conserved Domains (2) summary
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:2201
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
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