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MSI1 musashi RNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 4440, updated on 3-Dec-2022

Summary

Official Symbol
MSI1provided by HGNC
Official Full Name
musashi RNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7330
See related
Ensembl:ENSG00000135097 MIM:603328; AllianceGenome:HGNC:7330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues See more
Orthologs
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Genomic context

See MSI1 in Genome Data Viewer
Location:
12q24.31
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120339662..120369164, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120328507..120356341, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120779133..120806967, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene phospholipase A2 group IB Neighboring gene ribosomal protein S27 pseudogene 25 Neighboring gene Sharpr-MPRA regulatory region 12947

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of polysome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein Musashi homolog 1
Names
musashi-1
musashi1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414485.1NP_001401414.1  RNA-binding protein Musashi homolog 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC003982
  2. NM_001414486.1NP_001401415.1  RNA-binding protein Musashi homolog 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC003982
  3. NM_001414487.1NP_001401416.1  RNA-binding protein Musashi homolog 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC003982
  4. NM_001414488.1NP_001401417.1  RNA-binding protein Musashi homolog 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC003982
  5. NM_001414489.1NP_001401418.1  RNA-binding protein Musashi homolog 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC003982
  6. NM_001414490.1NP_001401419.1  RNA-binding protein Musashi homolog 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC003982
  7. NM_001414491.1NP_001401420.1  RNA-binding protein Musashi homolog 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC003982
  8. NM_001414492.1NP_001401421.1  RNA-binding protein Musashi homolog 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC003982
  9. NM_001414493.1NP_001401422.1  RNA-binding protein Musashi homolog 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC003982
  10. NM_001414494.1NP_001401423.1  RNA-binding protein Musashi homolog 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC003982
  11. NM_001414495.1NP_001401424.1  RNA-binding protein Musashi homolog 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC003982
  12. NM_001414496.1NP_001401425.1  RNA-binding protein Musashi homolog 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC003982
  13. NM_001414497.1NP_001401426.1  RNA-binding protein Musashi homolog 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC003982
  14. NM_001414498.1NP_001401427.1  RNA-binding protein Musashi homolog 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC003982
  15. NM_002442.4NP_002433.1  RNA-binding protein Musashi homolog 1 isoform a

    See identical proteins and their annotated locations for NP_002433.1

    Status: REVIEWED

    Source sequence(s)
    AB012851, AC003982, AI583233, BX393884
    Consensus CDS
    CCDS9196.1
    UniProtKB/Swiss-Prot
    O43347, Q96PU3
    Related
    ENSP00000257552.2, ENST00000257552.7
    Conserved Domains (3) summary
    TIGR01628
    Location:32339
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2196
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120339662..120369164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538361.4XP_011536663.1  RNA-binding protein Musashi homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011536663.1

    UniProtKB/Swiss-Prot
    O43347, Q96PU3
    Conserved Domains (3) summary
    TIGR01628
    Location:32339
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2196
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  2. XM_047428872.1XP_047284828.1  RNA-binding protein Musashi homolog 1 isoform X9

  3. XM_047428871.1XP_047284827.1  RNA-binding protein Musashi homolog 1 isoform X8

  4. XM_047428870.1XP_047284826.1  RNA-binding protein Musashi homolog 1 isoform X6

  5. XM_047428869.1XP_047284825.1  RNA-binding protein Musashi homolog 1 isoform X4

  6. XM_011538363.3XP_011536665.1  RNA-binding protein Musashi homolog 1 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:32329
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2196
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  7. XM_011538362.3XP_011536664.1  RNA-binding protein Musashi homolog 1 isoform X3

    Conserved Domains (3) summary
    TIGR01628
    Location:32320
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2196
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  8. XM_006719403.4XP_006719466.1  RNA-binding protein Musashi homolog 1 isoform X2

    Conserved Domains (3) summary
    TIGR01628
    Location:32328
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2196
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  9. XM_011538366.3XP_011536668.1  RNA-binding protein Musashi homolog 1 isoform X4

    See identical proteins and their annotated locations for XP_011536668.1

    Conserved Domains (2) summary
    TIGR01628
    Location:8236
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:780
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  10. XM_011538364.3XP_011536666.1  RNA-binding protein Musashi homolog 1 isoform X7

    Conserved Domains (2) summary
    COG0724
    Location:887
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:1083
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  11. XM_006719404.4XP_006719467.1  RNA-binding protein Musashi homolog 1 isoform X10

    See identical proteins and their annotated locations for XP_006719467.1

    Conserved Domains (2) summary
    TIGR01628
    Location:2201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily
  12. XM_011538371.3XP_011536673.1  RNA-binding protein Musashi homolog 1 isoform X10

    See identical proteins and their annotated locations for XP_011536673.1

    Conserved Domains (2) summary
    TIGR01628
    Location:2201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. XM_011538368.3XP_011536670.1  RNA-binding protein Musashi homolog 1 isoform X10

    See identical proteins and their annotated locations for XP_011536670.1

    Conserved Domains (2) summary
    TIGR01628
    Location:2201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily
  14. XM_011538370.3XP_011536672.1  RNA-binding protein Musashi homolog 1 isoform X10

    See identical proteins and their annotated locations for XP_011536672.1

    Conserved Domains (2) summary
    TIGR01628
    Location:2201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:145
    RRM_SF; RNA recognition motif (RRM) superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120328507..120356341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)