Format

Send to:

Choose Destination

ANKRD65 ankyrin repeat domain 65 [ Homo sapiens (human) ]

Gene ID: 441869, updated on 23-Nov-2021

Summary

Official Symbol
ANKRD65provided by HGNC
Official Full Name
ankyrin repeat domain 65provided by HGNC
Primary source
HGNC:HGNC:42950
See related
Ensembl:ENSG00000235098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in lung (RPKM 2.8), urinary bladder (RPKM 2.8) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ANKRD65 in Genome Data Viewer
Location:
1p36.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1418420..1422471, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1353800..1356656, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MRPL20 divergent transcript Neighboring gene uncharacterized LOC107984868 Neighboring gene ANKRD65 antisense RNA 1 Neighboring gene transmembrane protein 88B Neighboring gene long intergenic non-protein coding RNA 1770 Neighboring gene uncharacterized LOC107985729 Neighboring gene Sharpr-MPRA regulatory region 8235

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

General protein information

Preferred Names
ankyrin repeat domain-containing protein 65

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145210.3NP_001138682.1  ankyrin repeat domain-containing protein 65 isoform 1

    See identical proteins and their annotated locations for NP_001138682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL391244, BC018095, BC063445, BC094869
    Consensus CDS
    CCDS55558.1
    UniProtKB/Swiss-Prot
    E5RJM6
    Related
    ENSP00000445688.1, ENST00000537107.6
    Conserved Domains (3) summary
    cd00204
    Location:69192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:273364
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:268299
    ANK; ANK repeat [structural motif]
  2. NM_001243535.2NP_001230464.1  ankyrin repeat domain-containing protein 65 isoform 2

    See identical proteins and their annotated locations for NP_001230464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC018095, BC094869
    Consensus CDS
    CCDS57962.1
    UniProtKB/Swiss-Prot
    E5RJM6
    Related
    ENSP00000428419.1, ENST00000427211.3
  3. NM_001243536.2NP_001230465.1  ankyrin repeat domain-containing protein 65 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is significantly shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC094869
    Consensus CDS
    CCDS57963.1
    UniProtKB/Swiss-Prot
    E5RJM6
    Related
    ENSP00000429035.1, ENST00000520296.5
  4. NM_001375659.1NP_001362588.1  ankyrin repeat domain-containing protein 65 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC073150, BI755193, CD387703
    Related
    ENSP00000428201.1, ENST00000442470.1
  5. NM_001375660.1NP_001362589.1  ankyrin repeat domain-containing protein 65 isofom 3

    Status: VALIDATED

    Source sequence(s)
    AL391244

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1418420..1422471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001324.2XP_016856813.1  ankyrin repeat domain-containing protein 65 isoform X1

    UniProtKB/Swiss-Prot
    E5RJM6
    Conserved Domains (3) summary
    cd00204
    Location:69192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:273364
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:268299
    ANK; ANK repeat [structural motif]
  2. XM_005244752.4XP_005244809.1  ankyrin repeat domain-containing protein 65 isoform X1

    See identical proteins and their annotated locations for XP_005244809.1

    UniProtKB/Swiss-Prot
    E5RJM6
    Conserved Domains (3) summary
    cd00204
    Location:69192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:273364
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:268299
    ANK; ANK repeat [structural motif]
  3. XM_006710647.3XP_006710710.1  ankyrin repeat domain-containing protein 65 isoform X1

    See identical proteins and their annotated locations for XP_006710710.1

    UniProtKB/Swiss-Prot
    E5RJM6
    Conserved Domains (3) summary
    cd00204
    Location:69192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:273364
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:268299
    ANK; ANK repeat [structural motif]
  4. XM_011541489.2XP_011539791.1  ankyrin repeat domain-containing protein 65 isoform X1

    See identical proteins and their annotated locations for XP_011539791.1

    UniProtKB/Swiss-Prot
    E5RJM6
    Related
    ENSP00000482314.1, ENST00000454272.2
    Conserved Domains (3) summary
    cd00204
    Location:69192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:273364
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:268299
    ANK; ANK repeat [structural motif]
Support Center