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AKR1B15 aldo-keto reductase family 1 member B15 [ Homo sapiens (human) ]

Gene ID: 441282, updated on 21-Dec-2019

Summary

Official Symbol
AKR1B15provided by HGNC
Official Full Name
aldo-keto reductase family 1 member B15provided by HGNC
Primary source
HGNC:HGNC:37281
See related
Ensembl:ENSG00000227471 MIM:616336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKR1B10L; AKR1R1B7; AKR1B10L, AK1R1B7
Expression
Biased expression in stomach (RPKM 12.1), duodenum (RPKM 9.7) and 4 other tissues See more
Orthologs

Genomic context

See AKR1B15 in Genome Data Viewer
Location:
7q33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (134549110..134579869)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134233849..134264615)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group 3 member 1 pseudogene Neighboring gene aldo-keto reductase family 1 member B10 Neighboring gene uncharacterized LOC105375520 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4787 Neighboring gene bisphosphoglycerate mutase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP-retinol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
alcohol dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
allyl-alcohol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
estradiol 17-beta-dehydrogenase activity TAS
Traceable Author Statement
more info
 
farnesol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
testosterone 17-beta-dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
estrogen biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aldo-keto reductase family 1 member B15
Names
estradiol 17-beta-dehydrogenase AKR1B15
farnesol dehydrogenase
putative aldo-keto reductase family 1 member B15
testosterone 17beta-dehydrogenase
NP_001074007.2
NP_001354749.1
NP_001354750.1
NP_001354751.1
XP_016867713.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080538.3NP_001074007.2  aldo-keto reductase family 1 member B15 isoform a

    See identical proteins and their annotated locations for NP_001074007.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC078847, BX335355
    Consensus CDS
    CCDS47715.2
    UniProtKB/Swiss-Prot
    C9JRZ8
    Related
    ENSP00000389289.1, ENST00000457545.7
    Conserved Domains (2) summary
    COG0656
    Location:56325
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:57317
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. NM_001367820.1NP_001354749.1  aldo-keto reductase family 1 member B15 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC078847
  3. NM_001367821.1NP_001354750.1  aldo-keto reductase family 1 member B15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC078847
    Related
    ENSP00000498877.1, ENST00000652743.1
  4. NM_001367822.1NP_001354751.1  aldo-keto reductase family 1 member B15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC078847

RNA

  1. NR_160301.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC078847
    Related
    ENST00000467156.1
  2. NR_160302.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC078847

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    134549110..134579869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012224.2XP_016867713.1  aldo-keto reductase family 1 member B15 isoform X1

    UniProtKB/Swiss-Prot
    C9JRZ8
    Related
    ENSP00000397009.2, ENST00000423958.2
    Conserved Domains (2) summary
    COG0656
    Location:56325
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:57317
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
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