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MARCHF11 membrane associated ring-CH-type finger 11 [ Homo sapiens (human) ]

Gene ID: 441061, updated on 22-Sep-2022

Summary

Official Symbol
MARCHF11provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 11provided by HGNC
Primary source
HGNC:HGNC:33609
See related
Ensembl:ENSG00000183654 MIM:613338; AllianceGenome:HGNC:33609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF226; MARCH11; MARCH-XI
Summary
MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Expression
Restricted expression toward testis (RPKM 20.4) See more
Orthologs
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Genomic context

See MARCHF11 in Genome Data Viewer
Location:
5p15.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (16067139..16179791, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (16006508..16119114, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16067248..16179900, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986406 Neighboring gene RNA, 5S ribosomal pseudogene 178 Neighboring gene MARCHF11 antisense RNA 1 Neighboring gene uncharacterized LOC105379640 Neighboring gene MARCHF11 divergent transcript Neighboring gene NACA pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCHF11
Names
E3 ubiquitin-protein ligase MARCH11
RING-type E3 ubiquitin transferase MARCH11
RING-type E3 ubiquitin transferase MARCHF11
membrane associated ring finger 11
membrane-associated RING finger protein 11
membrane-associated RING-CH protein XI
membrane-associated ring finger (C3HC4) 11
NP_001096032.1
XP_047273186.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102562.3NP_001096032.1  E3 ubiquitin-protein ligase MARCHF11

    See identical proteins and their annotated locations for NP_001096032.1

    Status: VALIDATED

    Source sequence(s)
    AC016650, AC092335, BG209034, DB455291
    Consensus CDS
    CCDS47192.1
    UniProtKB/Swiss-Prot
    A6NNE9, A7E2S6
    Related
    ENSP00000333181.7, ENST00000332432.9
    Conserved Domains (1) summary
    smart00744
    Location:169215
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    16067139..16179791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417230.1XP_047273186.1  E3 ubiquitin-protein ligase MARCHF11 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    16006508..16119114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)