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PRAMEF11 PRAME family member 11 [ Homo sapiens (human) ]

Gene ID: 440560, updated on 11-Jun-2025
Official Symbol
PRAMEF11provided by HGNC
Official Full Name
PRAME family member 11provided by HGNC
Primary source
HGNC:HGNC:14086
See related
Ensembl:ENSG00000239810 AllianceGenome:HGNC:14086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Low expression observed in reference dataset See more
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See PRAMEF11 in Genome Data Viewer
Location:
1p36.21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12824605..12831410, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12368391..12375422, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12884463..12891264, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12858699-12859200 Neighboring gene long intergenic non-protein coding RNA 1784 Neighboring gene PRAME family member 30, pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein C like 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like ligase-substrate adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul2-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
PRAME family member 11

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146344.3NP_001139816.2  PRAME family member 11

    See identical proteins and their annotated locations for NP_001139816.2

    Status: VALIDATED

    Source sequence(s)
    AC245034
    Consensus CDS
    CCDS53268.2
    UniProtKB/Swiss-Prot
    A0A087WW85, B7ZMC2, O60813
    UniProtKB/TrEMBL
    B7ZW04
    Related
    ENSP00000480027.2, ENST00000619922.1
    Conserved Domains (1) summary
    cd21340
    Location:269393
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    12824605..12831410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541479.3XP_011539781.1  PRAME family member 11 isoform X1

    See identical proteins and their annotated locations for XP_011539781.1

    UniProtKB/Swiss-Prot
    A0A087WW85, B7ZMC2, O60813
    UniProtKB/TrEMBL
    B7ZW04
    Conserved Domains (1) summary
    cd21340
    Location:269393
    PPP1R42; protein phosphatase 1 regulatory subunit 42

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_012132914.1 Reference GRCh38.p14 PATCHES

    Range
    6118..12923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331861.1XP_054187836.1  PRAME family member 11 isoform X1

    UniProtKB/Swiss-Prot
    A0A087WW85, B7ZMC2, O60813
    UniProtKB/TrEMBL
    B7ZW04

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    12368391..12375422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336677.1XP_054192652.1  PRAME family member 11 isoform X1

    UniProtKB/TrEMBL
    B7ZW04