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PSG8 pregnancy specific beta-1-glycoprotein 8 [ Homo sapiens (human) ]

Gene ID: 440533, updated on 23-Nov-2021

Summary

Official Symbol
PSG8provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 8provided by HGNC
Primary source
HGNC:HGNC:9525
See related
Ensembl:ENSG00000124467 MIM:176397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG1
Summary
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 46.5) See more
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Genomic context

See PSG8 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42752686..42765692, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43256838..43269830, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene 28 Neighboring gene pregnancy specific beta-1-glycoprotein 3 Neighboring gene CEA cell adhesion molecule pseudogene 6 Neighboring gene PSG8 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp781L10202

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pregnancy-specific beta-1-glycoprotein 8
Names
C1 alternate
C2 alternate
C3 alternate
PS-beta-G-8
PSBG-8
pregnancy-specific beta-1 glycoprotein
pregnancy-specific glycoprotein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130167.2NP_001123639.1  pregnancy-specific beta-1-glycoprotein 8 isoform b precursor

    See identical proteins and their annotated locations for NP_001123639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC004654, BC137500, BC142628, BX114490
    Consensus CDS
    CCDS46091.1
    UniProtKB/Swiss-Prot
    Q9UQ74
    Related
    ENSP00000385869.3, ENST00000404209.8
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339411
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. NM_001130168.2NP_001123640.1  pregnancy-specific beta-1-glycoprotein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC004654, AL545004, BC137500, BC142628, BX114490
    Consensus CDS
    CCDS46090.1
    UniProtKB/Swiss-Prot
    Q9UQ74
    Related
    ENSP00000385081.3, ENST00000406636.7
    Conserved Domains (3) summary
    smart00410
    Location:217289
    IG_like; Immunoglobulin like
    pfam13895
    Location:213291
    Ig_2; Immunoglobulin domain
    cl11960
    Location:26114
    Ig; Immunoglobulin domain
  3. NM_182707.3NP_874366.1  pregnancy-specific beta-1-glycoprotein 8 isoform a precursor

    See identical proteins and their annotated locations for NP_874366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC137500
    Consensus CDS
    CCDS33037.1
    UniProtKB/Swiss-Prot
    Q9UQ74
    Related
    ENSP00000305005.4, ENST00000306511.5
    Conserved Domains (3) summary
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:148236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42752686..42765692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526986.1XP_011525288.1  pregnancy-specific beta-1-glycoprotein 8 isoform X1

    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246318
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. XM_011526988.2XP_011525290.1  pregnancy-specific beta-1-glycoprotein 8 isoform X3

    Conserved Domains (3) summary
    smart00410
    Location:178250
    IG_like; Immunoglobulin like
    pfam13895
    Location:174252
    Ig_2; Immunoglobulin domain
    cl11960
    Location:275
    Ig; Immunoglobulin domain
  3. XM_011526987.3XP_011525289.1  pregnancy-specific beta-1-glycoprotein 8 isoform X2

    Related
    ENST00000600709.5
    Conserved Domains (3) summary
    smart00410
    Location:226298
    IG_like; Immunoglobulin like
    pfam13895
    Location:222300
    Ig_2; Immunoglobulin domain
    cl11960
    Location:35123
    Ig; Immunoglobulin domain
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