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NPIPB4 nuclear pore complex interacting protein family member B4 [ Homo sapiens (human) ]

Gene ID: 440345, updated on 23-Nov-2021

Summary

Official Symbol
NPIPB4provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B4provided by HGNC
Primary source
HGNC:HGNC:41985
See related
Ensembl:ENSG00000185864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
61E3.4
Expression
Ubiquitous expression in skin (RPKM 29.6), bone marrow (RPKM 21.2) and 24 other tissues See more
Orthologs
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Genomic context

See NPIPB4 in Genome Data Viewer
Location:
16p12.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (21834568..21857756, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21845903..21869077, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene otoancorin Neighboring gene uncharacterized LOC105371126 Neighboring gene RRN3 pseudogene 1 Neighboring gene uncharacterized LOC112268174 Neighboring gene SMG1 pseudogene 4 Neighboring gene ABCA3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • KIAA0220

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear pore complex-interacting protein family member B4
Names
nuclear pore complex interacting protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310148.2NP_001297077.1  nuclear pore complex-interacting protein family member B4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC092375
    Conserved Domains (3) summary
    PHA03307
    Location:9551220
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:241
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_001384979.1NP_001371908.1  nuclear pore complex-interacting protein family member B4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC092375
    Conserved Domains (3) summary
    PHA03307
    Location:9551220
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:241
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. NM_001384980.1NP_001371909.1  nuclear pore complex-interacting protein family member B4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC092375
    Related
    ENSP00000507812.1, ENST00000682606.1
    Conserved Domains (3) summary
    PHA03307
    Location:9551220
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:241
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. NM_001384981.1NP_001371910.1  nuclear pore complex-interacting protein family member B4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC092375
    Conserved Domains (2) summary
    PHA03307
    Location:9521219
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:43300
    NPIP; Nuclear pore complex interacting protein (NPIP)
  5. NM_001384982.1NP_001371911.1  nuclear pore complex-interacting protein family member B4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092375
    Conserved Domains (2) summary
    PHA03307
    Location:9361201
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:27284
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    21834568..21857756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450289.1XP_024306057.1  nuclear pore complex-interacting protein family member B4 isoform X8

    Conserved Domains (3) summary
    pfam06409
    Location:41221
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:141
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl28033
    Location:703928
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  2. XM_017023247.1XP_016878736.1  nuclear pore complex-interacting protein family member B4 isoform X5

  3. XM_024450285.1XP_024306053.1  nuclear pore complex-interacting protein family member B4 isoform X4

    Related
    ENSP00000404439.2, ENST00000415645.6
    Conserved Domains (3) summary
    pfam06409
    Location:41221
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:141
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl28033
    Location:8801140
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  4. XM_017023244.2XP_016878733.1  nuclear pore complex-interacting protein family member B4 isoform X2

    Conserved Domains (3) summary
    PHA03307
    Location:9551220
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam06409
    Location:46303
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:241
    AFD_class_I; Adenylate forming domain, Class I superfamily
  5. XM_024450283.1XP_024306051.1  nuclear pore complex-interacting protein family member B4 isoform X1

    Conserved Domains (3) summary
    pfam06409
    Location:70250
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:141
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl28033
    Location:9841249
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  6. XM_024450284.1XP_024306052.1  nuclear pore complex-interacting protein family member B4 isoform X3

    Conserved Domains (2) summary
    pfam06409
    Location:39219
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl28033
    Location:9531220
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  7. XM_024450288.1XP_024306056.1  nuclear pore complex-interacting protein family member B4 isoform X7

    Conserved Domains (2) summary
    pfam06409
    Location:138
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl28033
    Location:7721039
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  8. XM_024450286.1XP_024306054.1  nuclear pore complex-interacting protein family member B4 isoform X6

    Conserved Domains (2) summary
    pfam06409
    Location:147
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl28033
    Location:7811048
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  9. XM_024450287.1XP_024306055.1  nuclear pore complex-interacting protein family member B4 isoform X7

    Conserved Domains (2) summary
    pfam06409
    Location:138
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl28033
    Location:7721039
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    1247282..1270193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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