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CARD17 caspase recruitment domain family member 17 [ Homo sapiens (human) ]

Gene ID: 440068, updated on 24-Nov-2020

Summary

Official Symbol
CARD17provided by HGNC
Official Full Name
caspase recruitment domain family member 17provided by HGNC
Primary source
HGNC:HGNC:33827
See related
Ensembl:ENSG00000255221 MIM:609490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INCA
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CARD17 in Genome Data Viewer
Location:
11q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (105080453..105101492, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (104963196..104972158, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984381 Neighboring gene caspase recruitment domain family member 16 Neighboring gene caspase 1 pseudogene 2 Neighboring gene caspase 1 pseudogene 3 Neighboring gene caspase 1 pseudogene 1 Neighboring gene caspase recruitment domain family member 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 17
Names
Inhibitory CARD
caspase-1 inhibitor INCA
inhibitory caspase recruitment domain (CARD) protein
inhibitory caspase recruitment domain protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007232.1NP_001007233.1  caspase recruitment domain-containing protein 17

    See identical proteins and their annotated locations for NP_001007233.1

    Status: VALIDATED

    Source sequence(s)
    AY761064
    Consensus CDS
    CCDS31662.1
    UniProtKB/Swiss-Prot
    Q5XLA6
    Related
    ENSP00000364859.1, ENST00000375707.1
    Conserved Domains (1) summary
    cd08325
    Location:587
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    105080453..105101492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448524.1XP_024304292.1  caspase recruitment domain-containing protein 17 isoform X1

    Conserved Domains (1) summary
    cd08325
    Location:20102
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
  2. XM_024448523.1XP_024304291.1  caspase recruitment domain-containing protein 17 isoform X1

    Conserved Domains (1) summary
    cd08325
    Location:20102
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
  3. XM_024448525.1XP_024304293.1  caspase recruitment domain-containing protein 17 isoform X1

    Conserved Domains (1) summary
    cd08325
    Location:20102
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
  4. XM_011542838.2XP_011541140.1  caspase recruitment domain-containing protein 17 isoform X1

    Conserved Domains (1) summary
    cd08325
    Location:20102
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RNA

  1. XR_002957149.1 RNA Sequence

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