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ASMT acetylserotonin O-methyltransferase [ Homo sapiens (human) ]

Gene ID: 438, updated on 26-Jul-2021

Summary

Official Symbol
ASMTprovided by HGNC
Official Full Name
acetylserotonin O-methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:750
See related
Ensembl:ENSG00000196433 MIM:300015; MIM:402500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASMTY; HIOMT; HIOMTY
Summary
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in ovary (RPKM 1.4), bone marrow (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See ASMT in Genome Data Viewer
Location:
X;Y
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (1595455..1643081)
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (1595455..1643081)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1714348..1761974)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1664348..1711974)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene P2Y receptor family member 8 Neighboring gene A-kinase anchoring protein 17A Neighboring gene uncharacterized LOC107985706 Neighboring gene uncharacterized LOC107985637

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene P2Y receptor family member 8 Neighboring gene A-kinase anchoring protein 17A Neighboring gene uncharacterized LOC107985706 Neighboring gene uncharacterized LOC107985637

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables S-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables acetylserotonin O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetylserotonin O-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aromatic compound biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in indolalkylamine biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in melatonin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in melatonin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in melatonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acetylserotonin O-methyltransferase
Names
acetylserotonin N-methyltransferase
acetylserotonin methyltransferase (Y chromosome)
hydroxyindole O-methyltransferase
NP_001164509.1
NP_001164510.1
NP_004034.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016337.1 RefSeqGene

    Range
    5001..52627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001171038.2NP_001164509.1  acetylserotonin O-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001164509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK314922, AL683807, BC001620, U11090, U11091
    Consensus CDS
    CCDS14117.1
    UniProtKB/Swiss-Prot
    P46597
    UniProtKB/TrEMBL
    A0A024RBT9
    Related
    ENSP00000370639.3, ENST00000381241.9
    Conserved Domains (2) summary
    pfam00891
    Location:105360
    Methyltransf_2; O-methyltransferase
    pfam16864
    Location:11100
    Dimerisation2; Dimerization domain
  2. NM_001171039.1NP_001164510.1  acetylserotonin O-methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001164510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is lacking two consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    BC001620, U11091
    Consensus CDS
    CCDS55364.1
    UniProtKB/Swiss-Prot
    P46597
    UniProtKB/TrEMBL
    X5D784
    Related
    ENSP00000370631.3, ENST00000381233.8
    Conserved Domains (2) summary
    pfam00891
    Location:105285
    Methyltransf_2; O-methyltransferase
    pfam16864
    Location:11100
    Dimerisation2; Dimerisation domain
  3. NM_004043.3NP_004034.2  acetylserotonin O-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_004034.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL683807, BC001620, U11090
    Consensus CDS
    CCDS14117.1
    UniProtKB/Swiss-Prot
    P46597
    UniProtKB/TrEMBL
    A0A024RBT9
    Conserved Domains (2) summary
    pfam00891
    Location:105360
    Methyltransf_2; O-methyltransferase
    pfam16864
    Location:11100
    Dimerisation2; Dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    1595455..1643081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    1595455..1643081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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