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S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740568, updated on 5-Jun-2021

Summary

Gene symbol
S
Gene description
surface glycoprotein
Locus tag
GU280_gp02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Also known as
spike glycoprotein
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The spike glycoprotein is found on the outside of the virus particle and gives coronavirus viruses their crown-like appearance. This glycoprotein mediates attachment of the virus particle and entry into the host cell. S protein is an important target for vaccine development, antibody therapies and diagnostic antigen-based tests.
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Genomic context

Sequence:
NC_045512.2 (21563..25384)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein;ORF1ab polyprotein Neighboring gene ORF3a protein Neighboring gene envelope protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
surface glycoprotein
YP_009724390.1
  • structural protein; spike protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    21563..25384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724390.1 surface glycoprotein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    Conserved Domains (5) summary
    cd21480
    Location:319541
    SARS-CoV-2_Spike_S1_RBD; receptor-binding domain of the S1 subunit of severe acute respiratory syndrome coronavirus 2 Spike (S) protein
    cd21624
    Location:13304
    SARS-CoV-like_Spike_S1_NTD; N-terminal domain of the S1 subunit of the Spike (S) protein from Severe acute respiratory syndrome coronavirus and related betacoronaviruses in the B lineage
    pfam19214
    Location:12331273
    CoV_S2_C; Coronavirus spike glycoprotein S2, intravirion
    cd21698
    Location:918983
    CoV_Spike_S1-S2_S2; heptad repeat 1 [structural motif]
    cl40439
    Location:5431208
    CoV_Spike_S1-S2_S2; S1/S2 cleavage region and the S2 fusion subunit of coronavirus spike (S) proteins
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