ap4m1 adaptor related protein complex 4 subunit mu 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ap4m1provided by ZNC
Official Full Name: adaptor related protein complex 4 subunit mu 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-421
See related: Ensembl:ENSDARG00000056871 AllianceGenome:ZFIN:ZDB-GENE-040718-421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91931; si:ch211-237l4.1
Summary: Predicted to be involved in Golgi to lysosome transport and protein targeting. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in Golgi apparatus; early endosome; and membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in cytoplasmic vesicle and trans-Golgi network. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human AP4M1 (adaptor related protein complex 4 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (22854794..22862078)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (22885351..22892626)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in Golgi to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein targeting	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AP-4 complex subunit mu-1

Names: adaptor-related protein complex 4, mu 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002672.1 → NP_001002672.1 AP-4 complex subunit mu-1

See identical proteins and their annotated locations for NP_001002672.1

Status: PROVISIONAL

Source sequence(s)

AL807389

UniProtKB/TrEMBL

B2GRN8, Q7SZZ7

Related

ENSDARP00000073893.5, ENSDART00000079437.6

Conserved Domains (2) summary

cl02092
Location:1 → 127

Clat_adaptor_s; Clathrin adaptor complex small chain

cd09253
Location:174 → 442

AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

22854794..22862078

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479156.2 → XP_021334831.1 AP-4 complex subunit mu-1 isoform X1

UniProtKB/TrEMBL

A0A8M9QGL0

Conserved Domains (2) summary

cl02092
Location:1 → 127

Clat_adaptor_s; Clathrin adaptor complex small chain

cl10970
Location:174 → 382

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)