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Lrrc8b leucine rich repeat containing 8 family, member B [ Mus musculus (house mouse) ]

Gene ID: 433926, updated on 5-Mar-2024

Summary

Official Symbol
Lrrc8bprovided by MGI
Official Full Name
leucine rich repeat containing 8 family, member Bprovided by MGI
Primary source
MGI:MGI:2141353
See related
Ensembl:ENSMUSG00000070639 AllianceGenome:MGI:2141353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ta-lrrp; mKIAA0231; 2210408K08Rik
Summary
Predicted to contribute to volume-sensitive anion channel activity. Predicted to be involved in anion transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be part of ion channel complex. Orthologous to human LRRC8B (leucine rich repeat containing 8 VRAC subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 142.7), adrenal adult (RPKM 13.7) and 5 other tissues See more
Orthologs
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Genomic context

Location:
5 E5; 5 50.68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105563072..105637945)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105415206..105490079)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26519 Neighboring gene STARR-positive B cell enhancer ABC_E8067 Neighboring gene RIKEN cDNA 4930542N06 gene Neighboring gene predicted gene, 32051 Neighboring gene STARR-seq mESC enhancer starr_13851 Neighboring gene STARR-seq mESC enhancer starr_13852 Neighboring gene STARR-positive B cell enhancer ABC_E6355 Neighboring gene predicted gene, 42141 Neighboring gene predicted gene, 42144

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0231

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic anion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of monoatomic ion channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
volume-regulated anion channel subunit LRRC8B
Names
T-cell activation leucine repeat-rich protein
leucine-rich repeat-containing protein 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033550.4NP_001028722.1  volume-regulated anion channel subunit LRRC8B

    See identical proteins and their annotated locations for NP_001028722.1

    Status: VALIDATED

    Source sequence(s)
    AC113980, AC138265
    Consensus CDS
    CCDS39193.1
    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Related
    ENSMUSP00000108327.2, ENSMUST00000112707.3
    Conserved Domains (4) summary
    PLN00113
    Location:428692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1334
    Pannexin_like; Pannexin-like TM region of LRRC8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105563072..105637945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254652.1XP_030110512.1  volume-regulated anion channel subunit LRRC8B isoform X1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1334
    Pannexin_like; Pannexin-like TM region of LRRC8
  2. XM_030254653.1XP_030110513.1  volume-regulated anion channel subunit LRRC8B isoform X1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1334
    Pannexin_like; Pannexin-like TM region of LRRC8
  3. XM_030254651.2XP_030110511.1  volume-regulated anion channel subunit LRRC8B isoform X1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1334
    Pannexin_like; Pannexin-like TM region of LRRC8
  4. XM_011249508.3XP_011247810.1  volume-regulated anion channel subunit LRRC8B isoform X1

    See identical proteins and their annotated locations for XP_011247810.1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1334
    Pannexin_like; Pannexin-like TM region of LRRC8