U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lrrc8b leucine rich repeat containing 8 family, member B [ Mus musculus (house mouse) ]

Gene ID: 433926, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Lrrc8bprovided by MGI
Official Full Name
leucine rich repeat containing 8 family, member Bprovided by MGI
Primary source
MGI:MGI:2141353
See related
Ensembl:ENSMUSG00000070639 AllianceGenome:MGI:2141353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ta-lrrp; mKIAA0231; 2210408K08Rik
Summary
Predicted to enable volume-sensitive anion channel activity. Predicted to be involved in several processes, including aspartate transmembrane transport; cyclic-GMP-AMP transmembrane import across plasma membrane; and monoatomic anion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8B (leucine rich repeat containing 8 VRAC subunit B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 142.7), adrenal adult (RPKM 13.7) and 5 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lrrc8b in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105563072..105637945)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105415206..105490079)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26519 Neighboring gene STARR-positive B cell enhancer ABC_E8067 Neighboring gene RIKEN cDNA 4930542N06 gene Neighboring gene predicted gene, 32051 Neighboring gene STARR-seq mESC enhancer starr_13851 Neighboring gene STARR-seq mESC enhancer starr_13852 Neighboring gene STARR-positive B cell enhancer ABC_E6355 Neighboring gene predicted gene, 42141 Neighboring gene predicted gene, 42144

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. López-Cayuqueo KI, et al. J Am Soc Nephrol, 2022 Aug. PMID 35777784, Free PMC Article
  2. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Zhou C, et al. Immunity, 2020 May 19. PMID 32277911
  3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0231

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables volume-sensitive anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to volume-sensitive anion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic anion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of monoatomic ion channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
volume-regulated anion channel subunit LRRC8B
Names
T-cell activation leucine repeat-rich protein
leucine-rich repeat-containing protein 8B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033550.4 → NP_001028722.1  volume-regulated anion channel subunit LRRC8B

    See identical proteins and their annotated locations for NP_001028722.1

    Status: VALIDATED

    Source sequence(s)
    AC113980, AC138265
    Consensus CDS
    CCDS39193.1
    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Related
    ENSMUSP00000108327.2, ENSMUST00000112707.3
    Conserved Domains (4) summary
    PLN00113
    Location:428 → 692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578 → 794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465 → 488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 334
    Pannexin_like; Pannexin-like TM region of LRRC8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105563072..105637945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254652.1 → XP_030110512.1  volume-regulated anion channel subunit LRRC8B isoform X1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428 → 692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578 → 794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465 → 488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 334
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_030254653.1 → XP_030110513.1  volume-regulated anion channel subunit LRRC8B isoform X1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428 → 692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578 → 794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465 → 488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 334
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_030254651.2 → XP_030110511.1  volume-regulated anion channel subunit LRRC8B isoform X1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428 → 692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578 → 794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465 → 488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 334
    Pannexin_like; Pannexin-like TM region of LRRC8

  4. XM_011249508.3 → XP_011247810.1  volume-regulated anion channel subunit LRRC8B isoform X1

    See identical proteins and their annotated locations for XP_011247810.1

    UniProtKB/Swiss-Prot
    B2RSI6, Q5DU41
    Conserved Domains (4) summary
    PLN00113
    Location:428 → 692
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:578 → 794
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:465 → 488
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 334
    Pannexin_like; Pannexin-like TM region of LRRC8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DU41.3 GenPept UniProtKB/Swiss-Prot:Q5DU41

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous