Sfta2 surfactant associated 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sfta2provided by MGI
Official Full Name: surfactant associated 2provided by MGI
Primary source: MGI:MGI:3643293
See related: Ensembl:ENSMUSG00000090509 AllianceGenome:MGI:3643293
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG433102
Summary: Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and extracellular region. Orthologous to human SFTA2 (surfactant associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward lung adult (RPKM 108.0) See more
Orthologs: human all
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Genomic context

Location:: 17; 17 B1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35960600..35961461)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35649708..35650569)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content.
Title: Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content.
SFTA2 was characterized as a novel unique secretory peptide highly expressed in the lung.
Title: SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Homology

Orthologs from Annotation Pipeline: 180 organisms have orthologs with human gene Sfta2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: surfactant-associated protein 2

Names: surfactant-associated protein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163194.1 → NP_001156666.1 surfactant-associated protein 2 precursor

Status: VALIDATED

Source sequence(s)

AK087178

Consensus CDS

CCDS50093.1

UniProtKB/Swiss-Prot

E9PXB6

Related

ENSMUSP00000132839.3, ENSMUST00000171166.3

Conserved Domains (1) summary

pfam15210
Location:19 → 77

SFTA2; Surfactant-associated protein 2