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MN1 MN1 proto-oncogene, transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 4330, updated on 12-Oct-2019

Summary

Official Symbol
MN1provided by HGNC
Official Full Name
MN1 proto-oncogene, transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:7180
See related
Ensembl:ENSG00000169184 MIM:156100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGCR; MGCR1; MGCR1-PEN; dJ353E16.2
Summary
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 2.3), esophagus (RPKM 2.2) and 21 other tissues See more
Orthologs

Genomic context

See MN1 in Genome Data Viewer
Location:
22q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (27748277..27801756, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (28144265..28197486, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372981 Neighboring gene Sharpr-MPRA regulatory regions 2672 and 6919 Neighboring gene uncharacterized LOC107985529 Neighboring gene VISTA enhancer hs1271

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meningioma, familial
MedGen: C3551915 OMIM: 607174 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
NHGRI GWA Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
intramembranous ossification IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
transcriptional activator MN1
Names
meningioma (disrupted in balanced translocation) 1
meningioma (translocation balanced)
meningioma chromosome region 1
probable tumor suppressor protein MN1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023258.1 RefSeqGene

    Range
    4743..58222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002430.3NP_002421.3  transcriptional activator MN1

    See identical proteins and their annotated locations for NP_002421.3

    Status: REVIEWED

    Source sequence(s)
    AL031591, X82209
    Consensus CDS
    CCDS42998.1
    UniProtKB/Swiss-Prot
    Q10571
    UniProtKB/TrEMBL
    A0A024R1C3
    Related
    ENSP00000304956.4, ENST00000302326.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    27748277..27801756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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