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MN1 MN1 proto-oncogene, transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 4330, updated on 20-Nov-2023

Summary

Official Symbol
MN1provided by HGNC
Official Full Name
MN1 proto-oncogene, transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:7180
See related
Ensembl:ENSG00000169184 MIM:156100; AllianceGenome:HGNC:7180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGCR; MGCR1; CEBALID; MGCR1-PEN; dJ353E16.2
Summary
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 2.3), esophagus (RPKM 2.2) and 21 other tissues See more
Orthologs
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Genomic context

See MN1 in Genome Data Viewer
Location:
22q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (27748277..27801756, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (28209592..28263071, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (28144265..28197744, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27937522-27938022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27938023-27938523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27957435-27957934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27969749-27970322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27971900-27972400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27972401-27972901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27987245-27987744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999453-27999970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999971-28000486 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28026616-28027234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28029867-28030460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28033379-28033879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034092-28034896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034897-28035700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28037955-28038888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28050431-28050930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28063419-28063918 Neighboring gene Sharpr-MPRA regulatory regions 2672 and 6919 Neighboring gene uncharacterized LOC124905098 Neighboring gene cytoplasmic mesoderm regulator Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:28113736-28114935 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28138905-28139406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28138404-28138904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28142924-28143424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28145441-28146311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28153780-28154462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28161389-28161890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28161891-28162390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28175917-28176543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28181385-28181912 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr22:28186882-28187858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28194718-28195264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28195265-28195810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28200153-28200717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28200718-28201281 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28205997-28206518 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28206519-28207040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28217251-28217750 Neighboring gene uncharacterized LOC107985529 Neighboring gene VISTA enhancer hs1271 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:28246273-28246791 Neighboring gene phosphatidylinositol transfer protein beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28314444-28315429

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
EBI GWAS Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional activator MN1
Names
meningioma (disrupted in balanced translocation) 1
meningioma (translocation balanced)
meningioma chromosome region 1
probable tumor suppressor protein MN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023258.1 RefSeqGene

    Range
    4743..58222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002430.3NP_002421.3  transcriptional activator MN1

    See identical proteins and their annotated locations for NP_002421.3

    Status: REVIEWED

    Source sequence(s)
    AL031591, X82209
    Consensus CDS
    CCDS42998.1
    UniProtKB/Swiss-Prot
    A9Z1V9, Q10571
    UniProtKB/TrEMBL
    A5HML1
    Related
    ENSP00000304956.4, ENST00000302326.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    27748277..27801756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    28209592..28263071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)