MMP16 matrix metallopeptidase 16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MMP16provided by HGNC
Official Full Name: matrix metallopeptidase 16provided by HGNC
Primary source: HGNC:HGNC:7162
See related: Ensembl:ENSG00000156103 MIM:602262
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Expression: Biased expression in brain (RPKM 3.8), gall bladder (RPKM 1.9) and 12 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 8q21.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	8	NC_000008.11 (88032009..88327483, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (89049460..89339717, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOXA11-AS could promote renal cancer cells growth and invasion by modulating miR-146b-5p-MMP16 axis.
Title: HOXA11-AS promotes the growth and invasion of renal cancer by sponging miR-146b-5p to upregulate MMP16 expression.
Overexpression of MMP2 and MMP16 in endometrial cancerous tissues corresponded to down-regulation of miR-377, miR-382 and miR-410, while decreased expression of TIMP2 was associated with miR-200b up-regulation.
Title: Post-transcriptional Regulation of MMP16 and TIMP2 Expression <i>via</i> miR-382, miR-410 and miR-200b in Endometrial Cancer.
MMP16 was highly expressed and correlated with poor prognosis in gastric cancer patients by promoting proliferation and invasion of gastric cancer cells
Title: MMP16 is a marker of poor prognosis in gastric cancer promoting proliferation and invasion.
Findings suggest that these MMP16 rs10090371, ADAMTS3 rs788935, TLL2 rs10882807 and MMP9 rs3918251 may be promising prognostic biomarkers for cutaneous melanoma specific survival (CMSS).
Title: Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
the present findings indicate that MT3-MMP is down-regulated in ESCC, which correlates to lymph node metastasis and poor survival of patients with this disease.
Title: MT3-MMP down-regulation promotes tumorigenesis and correlates to poor prognosis in esophageal squamous cell carcinoma.
more severe intervertebral disc degeneration is correlated with higher matrix metallopeptidase 16
Title: Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration.
results suggest that miR-145 functions as a tumor metastasis suppressor gene by down-regulating MMP16 and may be a potential target in osteosarcoma treatment
Title: MicroRNA-145 Suppresses Osteosarcoma Metastasis via Targeting MMP16.
the results support a role for MMP16 in promoting invasive properties of the meningioma tumours
Title: A role for matrix remodelling proteins in invasive and malignant meningiomas.
These results demonstrate that the MT3-MMP promoter is frequently hypermethylated in colorectal cancer and that downregulation of MT3-MMP may be important for cell migration in colorectal cancer.
Title: Promoter hypermethylation of membrane type 3 matrix metalloproteinase is associated with cell migration in colorectal adenocarcinoma.
MMP16 is a putative indicator of adverse melanoma prognosis.
Title: MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies five new schizophrenia loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide meta-analysis identifies new susceptibility loci for migraine. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AB021228 (e-PCR)
- UniSTS:163337

D5Wox36 (e-PCR)
- UniSTS:239940

RH121221 (e-PCR)
- UniSTS:138332

Mmp16 (e-PCR), detects polymorphism
- UniSTS:495993

A008T27 (e-PCR)
- UniSTS:62074

RH120085 (e-PCR)
- UniSTS:133515

D8S1400E (e-PCR)
- UniSTS:151196

D8S1404E (e-PCR)
- UniSTS:151198

D8S1425E (e-PCR)
- UniSTS:151214

WI-21150 (e-PCR)
- UniSTS:15287

A008X11 (e-PCR)
- UniSTS:59849

RH91779 (e-PCR)
- UniSTS:84947

RH120010 (e-PCR)
- UniSTS:133334

RH123289 (e-PCR)
- UniSTS:135666

MMP16_920 (e-PCR)
- UniSTS:277491

Homology

Homologs of the MMP16 gene: The MMP16 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 231 organisms have orthologs with human gene MMP16
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enzyme activator activity	TAS Traceable Author Statement more info	PubMed
metalloaminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
metalloaminopeptidase activity	TAS Traceable Author Statement more info	PubMed
metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
craniofacial suture morphogenesis	IEA Inferred from Electronic Annotation more info
embryonic cranial skeleton morphogenesis	IEA Inferred from Electronic Annotation more info
endochondral ossification	IEA Inferred from Electronic Annotation more info
extracellular matrix disassembly	TAS Traceable Author Statement more info
extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
protein metabolic process	TAS Traceable Author Statement more info	PubMed
protein processing	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IDA Inferred from Direct Assay more info	PubMed
proteolysis	TAS Traceable Author Statement more info	PubMed
skeletal system development	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
Golgi lumen	TAS Traceable Author Statement more info
cell surface	IEA Inferred from Electronic Annotation more info
extracellular matrix	IEA Inferred from Electronic Annotation more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: matrix metalloproteinase-16

Names: MMP-16; MT-MMP 3; MT3MMP; MTMMP3; Putative transmembrane protein C8orf57; matrix metallopeptidase 16 (membrane-inserted); membrane-type matrix metalloproteinase 3; membrane-type-3 matrix metalloproteinase

NP_005932.2

EC 3.4.24.-

XP_024302922.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005941.5 → NP_005932.2 matrix metalloproteinase-16 precursor

See identical proteins and their annotated locations for NP_005932.2

Status: REVIEWED

Source sequence(s)

AC037450, AL832595, D83646, DA575789

Consensus CDS

CCDS6246.1

UniProtKB/Swiss-Prot

P51512

Related

ENSP00000286614.6, ENST00000286614.11

Conserved Domains (5) summary

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:42 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)

cl26464
Location:292 → 338

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p13 Primary Assembly

Range

88032009..88327483 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024447154.1 → XP_024302922.1 matrix metalloproteinase-16 isoform X1

Conserved Domains (4) summary

cd00094
Location:77 → 269

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam11857
Location:274 → 344

DUF3377; Domain of unknown function (DUF3377)

cl26464
Location:29 → 75

Atrophin-1; Atrophin-1 family

cl27698
Location:1 → 28

Peptidase_M10; Matrixin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_022564.3: Suppressed sequence

Description

NM_022564.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_032297.1: Suppressed sequence

Description

NM_032297.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.