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MMP16 matrix metallopeptidase 16 [ Homo sapiens (human) ]

Gene ID: 4325, updated on 1-Aug-2020

Summary

Official Symbol
MMP16provided by HGNC
Official Full Name
matrix metallopeptidase 16provided by HGNC
Primary source
HGNC:HGNC:7162
See related
Ensembl:ENSG00000156103 MIM:602262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Expression
Biased expression in brain (RPKM 3.8), gall bladder (RPKM 1.9) and 12 other tissues See more
Orthologs

Genomic context

See MMP16 in Genome Data Viewer
Location:
8q21.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (88032009..88327483, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (89049460..89339717, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 4 like 2 Neighboring gene uncharacterized LOC105375628 Neighboring gene uncharacterized LOC105375630 Neighboring gene RNA, 5S ribosomal pseudogene 272 Neighboring gene uncharacterized protein C12orf29 homolog Neighboring gene uncharacterized LOC105375629

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association study identifies five new schizophrenia loci.
NHGRI GWA Catalog
Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761D112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
metalloaminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloaminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
craniofacial suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
protein metabolic process TAS
Traceable Author Statement
more info
PubMed 
protein processing IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
matrix metalloproteinase-16
Names
MMP-16
MT-MMP 3
MT3MMP
MTMMP3
Putative transmembrane protein C8orf57
matrix metallopeptidase 16 (membrane-inserted)
membrane-type matrix metalloproteinase 3
membrane-type-3 matrix metalloproteinase
NP_005932.2
XP_024302922.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005941.5NP_005932.2  matrix metalloproteinase-16 precursor

    See identical proteins and their annotated locations for NP_005932.2

    Status: REVIEWED

    Source sequence(s)
    AC037450, AL832595, D83646, DA575789
    Consensus CDS
    CCDS6246.1
    UniProtKB/Swiss-Prot
    P51512
    Related
    ENSP00000286614.6, ENST00000286614.11
    Conserved Domains (5) summary
    cd00094
    Location:340532
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:126291
    Peptidase_M10; Matrixin
    pfam01471
    Location:4296
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:537607
    DUF3377; Domain of unknown function (DUF3377)
    cl26464
    Location:292338
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    88032009..88327483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447154.1XP_024302922.1  matrix metalloproteinase-16 isoform X1

    Conserved Domains (4) summary
    cd00094
    Location:77269
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam11857
    Location:274344
    DUF3377; Domain of unknown function (DUF3377)
    cl26464
    Location:2975
    Atrophin-1; Atrophin-1 family
    cl27698
    Location:128
    Peptidase_M10; Matrixin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022564.3: Suppressed sequence

    Description
    NM_022564.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_032297.1: Suppressed sequence

    Description
    NM_032297.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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