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CG5521 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43242, updated on 18-Sep-2024

Summary

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Official Symbol
CG5521provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039466
Locus tag
Dmel_CG5521
See related
AllianceGenome:FB:FBgn0039466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5521; EP3527; FBpp0084441
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of GTPase activity and regulation of small GTPase mediated signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1) and RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
97D11-97D12; 3-92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26966930..26977878)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22792652..22803600)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tetraspanin 97E Neighboring gene Gustatory receptor 97a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of the Ras-like small GTPases and their regulators. van Dam TJ, et al. Small GTPases, 2011 Jan. PMID 21686276, Free PMC Article
  2. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
  3. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
  4. A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. Kraut R, et al. Curr Biol, 2001 Mar 20. PMID 11301252
  5. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Bernards A. Biochim Biophys Acta, 2003 Mar 17. PMID 12618308

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5521-PA
CG5521-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26966930..26977878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170277.2 → NP_001163748.1  uncharacterized protein Dmel_CG5521, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIZ3
    Conserved Domains (1) summary
    pfam02145
    Location:1648 → 1820
    Rap_GAP; Rap/ran-GAP

  2. NM_143259.3 → NP_651516.1  uncharacterized protein Dmel_CG5521, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651516.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058W5, Q9VB98
    Related
    FBpp0084441
    Conserved Domains (1) summary
    pfam02145
    Location:1642 → 1814
    Rap_GAP; Rap/ran-GAP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIZ3 E1JIZ3
Q9VB98.2 Q9VB98

Gene LinkOut

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