Vps33B Vacuolar protein sorting 33B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vps33Bprovided by FlyBase
Official Full Name: Vacuolar protein sorting 33Bprovided by FlyBase
Primary source: FLYBASE:FBgn0039335
Locus tag: Dmel_CG5127
See related: AllianceGenome:FB:FBgn0039335
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5127; Dmel\CG5127; dVps33B; Vps 33B; Vps33b; VPS33b; VPS33B
Summary: Enables syntaxin binding activity. Involved in cellular response to peptidoglycan; defense response to bacterium; and immune response. Part of HOPS complex. Is expressed in adult head. Used to study ARC syndrome. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; arthrogryposis, renal dysfunction, and cholestasis 1; cholestasis; and kidney disease. Orthologous to human VPS33B (VPS33B late endosome and lysosome associated). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25473490..25475756)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21299212..21301478)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to peptidoglycan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of SNARE complex assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CORVET complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CORVET complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of HOPS complex	IDA Inferred from Direct Assay more info	PubMed
part_of HOPS complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info