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CycB3 Cyclin B3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42971, updated on 26-Apr-2024

Summary

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Official Symbol
CycB3provided by FlyBase
Official Full Name
Cyclin B3provided by FlyBase
Primary source
FLYBASE:FBgn0015625
Locus tag
Dmel_CG5814
See related
AllianceGenome:FB:FBgn0015625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.414; CG5814; Cyc B3; cycB3; Dmel\CG5814; l(3)L6540
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in mitotic cytokinesis; regulation of chromatin binding activity; and syncytial blastoderm mitotic cell cycle. Located in nucleus. Is expressed in several structures, including ectoderm; embryonic brain; embryonic/larval nervous system; extended germ band embryo; and neuroblasts. Orthologous to human CCNB3 (cyclin B3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
96B1-96B1; 3-86 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24867934..24870816, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20693656..20696538, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sting-regulated gene 1 Neighboring gene Elastin-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Yuan K, et al. Curr Biol, 2015 Mar 16. PMID 25754637, Free PMC Article
  2. Whole-genome analysis of animal A- and B-type cyclins. Nieduszynski CA, et al. Genome Biol, 2002. PMID 12537559, Free PMC Article
  3. Cyclin specificity: how many wheels do you need on a unicycle? Miller ME, et al. J Cell Sci, 2001 May. PMID 11329367
  4. Regulating the onset of mitosis. Ohi R, et al. Curr Opin Cell Biol, 1999 Apr. PMID 10209160
  5. 3' non-translated sequences in Drosophila cyclin B transcripts direct posterior pole accumulation late in oogenesis and peri-nuclear association in syncytial embryos. Dalby B, et al. Development, 1992 Aug. PMID 1451670

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
    Title: Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
  2. overexpression of cycB3 dramatically increases the cystoblast(CB) number in Drosophila ovaries, suggesting that an excess of cycB3 function delays CB differentiation. Given that the cycB3 gene is evolutionarily conserved, from insects to humans, cycB3 may also be involved in controlling the fate of germline stem cells in humans.
    Title: Cyclin B3 Deficiency Impairs Germline Stem Cell Maintenance and Its Overexpression Delays Cystoblast Differentiation in Drosophila Ovary.
  3. Changing Cyclin B3 levels showed that it accelerated progress to anaphase, even in the absence of spindle assembly checkpoint function.
    Title: Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromatin binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in syncytial blastoderm mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin B3
Names
CG5814-PA
CG5814-PB
CycB3-PA
CycB3-PB
CyclinB3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24867934..24870816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276005.1 → NP_001262934.1  cyclin B3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262934.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96718, Q9I7I0, Q9TYG8
    UniProtKB/TrEMBL
    A0A0B4KHT9
    Conserved Domains (2) summary
    pfam00134
    Location:308 → 433
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:435 → 555
    Cyclin_C; Cyclin, C-terminal domain

  2. NM_143046.3 → NP_651303.2  cyclin B3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651303.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96718, Q9I7I0, Q9TYG8
    UniProtKB/TrEMBL
    A0A0B4KHT9
    Related
    FBpp0084103
    Conserved Domains (2) summary
    pfam00134
    Location:308 → 433
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:435 → 555
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHT9 A0A0B4KHT9
Q9I7I0.1 Q9I7I0

Gene LinkOut

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