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MEP1A meprin A subunit alpha [ Homo sapiens (human) ]

Gene ID: 4224, updated on 1-Aug-2020

Summary

Official Symbol
MEP1Aprovided by HGNC
Official Full Name
meprin A subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:7015
See related
Ensembl:ENSG00000112818 MIM:600388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPHA
Expression
Biased expression in small intestine (RPKM 216.8), duodenum (RPKM 122.1) and 1 other tissue See more
Orthologs

Genomic context

See MEP1A in Genome Data Viewer
Location:
6p12.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46793384..46845987)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46761094..46807519)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tudor domain containing 6 Neighboring gene phospholipase A2 group VII Neighboring gene ankyrin repeat domain 66 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene ADGRF5 antisense RNA 1 Neighboring gene uncharacterized LOC105375080

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
meprin A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
meprin A subunit alpha
Names
N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
PABA peptide hydrolase
PPH alpha
bA268F1.1 (meprin A alpha (PABA peptide hydrolase))
endopeptidase-2
meprin A, alpha (PABA peptide hydrolase)
NP_005579.2
XP_011512930.1
XP_011512931.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005588.3NP_005579.2  meprin A subunit alpha precursor

    See identical proteins and their annotated locations for NP_005579.2

    Status: VALIDATED

    Source sequence(s)
    AF478685, DA432559
    Consensus CDS
    CCDS4918.1
    UniProtKB/Swiss-Prot
    Q16819
    Related
    ENSP00000230588.4, ENST00000230588.9
    Conserved Domains (6) summary
    cd06263
    Location:269431
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:264431
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00054
    Location:672710
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd03783
    Location:431594
    MATH_Meprin_Alpha; Meprin family, Alpha subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
    cd04282
    Location:30259
    ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
    pfam01400
    Location:73261
    Astacin; Astacin (Peptidase family M12A)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    46793384..46845987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514628.1XP_011512930.1  meprin A subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011512930.1

    UniProtKB/TrEMBL
    B7ZL91
    Related
    ENSP00000480465.1, ENST00000611727.1
    Conserved Domains (6) summary
    cd06263
    Location:297459
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:292459
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00054
    Location:700738
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd03783
    Location:459622
    MATH_Meprin_Alpha; Meprin family, Alpha subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
    cd04282
    Location:58287
    ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
    pfam01400
    Location:101289
    Astacin; Astacin (Peptidase family M12A)
  2. XM_011514629.2XP_011512931.1  meprin A subunit alpha isoform X2

    Conserved Domains (6) summary
    cd06263
    Location:269431
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:264431
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd03783
    Location:431594
    MATH_Meprin_Alpha; Meprin family, Alpha subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
    cd04282
    Location:30259
    ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
    pfam00008
    Location:674695
    EGF; EGF-like domain
    pfam01400
    Location:73261
    Astacin; Astacin (Peptidase family M12A)
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