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MEIS1 Meis homeobox 1 [ Homo sapiens (human) ]

Gene ID: 4211, updated on 10-Oct-2019

Summary

Official Symbol
MEIS1provided by HGNC
Official Full Name
Meis homeobox 1provided by HGNC
Primary source
HGNC:HGNC:7000
See related
Ensembl:ENSG00000143995 MIM:601739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 17.9), adrenal (RPKM 12.6) and 21 other tissues See more
Orthologs

Genomic context

See MEIS1 in Genome Data Viewer
Location:
2p14
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (66435125..66573869)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (66662257..66799891)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene E4 enhancer upstream of MEIS1 Neighboring gene long intergenic non-protein coding RNA 1873 Neighboring gene MEIS1 5' regulatory region Neighboring gene MEIS1 antisense RNA 3 Neighboring gene E2 enhancer in MEIS1 Neighboring gene HHc2:066588 enhancer in MEIS1 Neighboring gene MEIS1 antisense RNA 2 Neighboring gene E5 enhancer in MEIS1 Neighboring gene HHc2:066628 enhancer in MEIS1 Neighboring gene E7 enhancer in MEIS1 Neighboring gene HCNR606 enhancer in MEIS1 Neighboring gene HHc2:066650 enhancer in MEIS1 Neighboring gene HCNR617 enhancer in MEIS1 Neighboring gene HHc2:066659 enhancer in MEIS1 Neighboring gene HHc2:067135 enhancer in MEIS1 Neighboring gene HHc2:067347 enhancer downstream of MEIS1 Neighboring gene long intergenic non-protein coding RNA 1798 Neighboring gene long intergenic non-protein coding RNA 1797

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic determinants of P wave duration and PR segment.
NHGRI GWA Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
NHGRI GWA Catalog
Genome-wide association studies of the PR interval in African Americans.
NHGRI GWA Catalog
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
NHGRI GWA Catalog
Genome-wide association study of PR interval.
NHGRI GWA Catalog
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
NHGRI GWA Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
NHGRI GWA Catalog
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC43380

Gene Ontology Provided by GOA

Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homeobox protein Meis1
Names
Meis1, myeloid ecotropic viral integration site 1 homolog
WUGSC:H_NH0444B04.1
leukemogenic homolog protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011467.1 RefSeqGene

    Range
    4726..143470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002398.3NP_002389.1  homeobox protein Meis1

    See identical proteins and their annotated locations for NP_002389.1

    Status: REVIEWED

    Source sequence(s)
    AC007392, AC092669, AI203963, AL832770, BC043503, CB854199, U85707
    Consensus CDS
    CCDS46309.1
    UniProtKB/Swiss-Prot
    O00470
    Related
    ENSP00000272369.8, ENST00000272369.14
    Conserved Domains (2) summary
    pfam05920
    Location:290329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108191
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    66435125..66573869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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