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OVALX ovalbumin-related protein X (SERPINB14C) [ Gallus gallus (chicken) ]

Gene ID: 420898, updated on 17-Aug-2024

Summary

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Official Symbol
OVALXprovided by CGNC
Official Full Name
ovalbumin-related protein X (SERPINB14C)provided by CGNC
Primary source
CGNC:51367
See related
Ensembl:ENSGALG00010011714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SERPINB11; SERPINB14C
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Genomic context

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Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (67456353..67463354, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (67429566..67436588, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene ovalbumin (SERPINB14) Neighboring gene ovalbumin-related protein Y (SERPINB14B) Neighboring gene uncharacterized LOC107052628 Neighboring gene serpin family B member 12 Neighboring gene serpin family B member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Migration of chicken egg-white protein ovalbumin-related protein X and its alteration in heparin-binding affinity during embryogenesis of fertilized egg. Akazawa T, et al. Poult Sci, 2019 Oct 1. PMID 31222360
  2. Ovalbumin-related protein X is a heparin-binding ov-serpin exhibiting antimicrobial activities. Réhault-Godbert S, et al. J Biol Chem, 2013 Jun 14. PMID 23615912, Free PMC Article
  3. Avian SERPINB11 gene: characteristics, tissue-specific expression, and regulation of expression by estrogen. Lim W, et al. Biol Reprod, 2011 Dec. PMID 21849706
  4. The ovalbumin gene family: structure of the X gene and evolution of duplicated split genes. Heilig R, et al. Cell, 1980 Jul. PMID 7418002
  5. The Family Secrets of Avian Egg-Specific Ovalbumin and Its Related Proteins Y and X. Da Silva M, et al. Biol Reprod, 2015 Sep. PMID 26157071

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although heparin-binding ability of egg-white OVAX slightly decreases during embryogenesis, OVAX incorporated into embryo can retain heparin-binding affinity.
    Title: Migration of chicken egg-white protein ovalbumin-related protein X and its alteration in heparin-binding affinity during embryogenesis of fertilized egg.
  2. Considering the antibacterial activities of OVAX, this protein might play a role in egg defense
    Title: The Family Secrets of Avian Egg-Specific Ovalbumin and Its Related Proteins Y and X.
  3. OVAX and ovalbumin, although highly similar in sequence, have peculiar sequential and/or structural features that are likely to impact their respective biological functions.
    Title: Ovalbumin-related protein X is a heparin-binding ov-serpin exhibiting antimicrobial activities.
  4. expressed only in epithelial cells of the chicken oviduct, implicated in regulation of oviduct development
    Title: Avian SERPINB11 gene: characteristics, tissue-specific expression, and regulation of expression by estrogen.
  5. SERPINB11 has a role in ovarian endometrioid carcinoma in chickens and human
    Title: Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ovalbumin-related protein X
Names
clade B (ovalbumin) pseudogene 1
gene X protein
serpin peptidase inhibitor, clade B (ovalbumin), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276386.2 → NP_001263315.2  ovalbumin-related protein X

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0Y614, R9TNA6
    Related
    ENSGALP00010016079.1, ENSGALT00010028030.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    67456353..67463354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015282174.3 → XP_015137660.2  ovalbumin-related protein X isoform X2

    UniProtKB/TrEMBL
    R9TNA6
    Conserved Domains (1) summary
    cl38926
    Location:11 → 402
    serpin; SERine Proteinase INhibitors (serpin) family

  2. XM_015282173.3 → XP_015137659.2  ovalbumin-related protein X isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAS0
    Related
    ENSGALP00010016073.1, ENSGALT00010028022.1
    Conserved Domains (1) summary
    cl38926
    Location:70 → 456
    serpin; SERine Proteinase INhibitors (serpin) family

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    67429566..67436588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911434.1 → XP_046767390.1  ovalbumin-related protein X isoform X2

    UniProtKB/TrEMBL
    R9TNA6

  2. XM_046911433.1 → XP_046767389.1  ovalbumin-related protein X isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAS0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01013.1 GenPept UniProtKB/Swiss-Prot:P01013

Gene LinkOut

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