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SMCP sperm mitochondria associated cysteine rich protein [ Homo sapiens (human) ]

Gene ID: 4184, updated on 23-Nov-2021

Summary

Official Symbol
SMCPprovided by HGNC
Official Full Name
sperm mitochondria associated cysteine rich proteinprovided by HGNC
Primary source
HGNC:HGNC:6962
See related
Ensembl:ENSG00000163206 MIM:601148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCS; MCSP; HSMCSGEN1
Summary
Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 221.5) See more
Orthologs
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Genomic context

See SMCP in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (152878322..152885047)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152850798..152857523)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371444 Neighboring gene uncharacterized LOC105371445 Neighboring gene IVL promoter region Neighboring gene involucrin Neighboring gene long intergenic non-protein coding RNA 1527 Neighboring gene small proline rich protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26305, MGC26519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in penetration of zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sperm mitochondrial-associated cysteine-rich protein
Names
testicular tissue protein Li 119
testicular tissue protein Li 161

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030663.3NP_109588.2  sperm mitochondrial-associated cysteine-rich protein

    See identical proteins and their annotated locations for NP_109588.2

    Status: REVIEWED

    Source sequence(s)
    BC014593
    Consensus CDS
    CCDS1029.1
    UniProtKB/Swiss-Prot
    P49901
    UniProtKB/TrEMBL
    Q5T7P5
    Related
    ENSP00000357754.3, ENST00000368765.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    152878322..152885047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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