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MC5R melanocortin 5 receptor [ Homo sapiens (human) ]

Gene ID: 4161, updated on 18-Aug-2020

Summary

Official Symbol
MC5Rprovided by HGNC
Official Full Name
melanocortin 5 receptorprovided by HGNC
Primary source
HGNC:HGNC:6933
See related
Ensembl:ENSG00000176136 MIM:600042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MC2
Summary
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
Orthologs

Genomic context

See MC5R in Genome Data Viewer
Location:
18p11.21
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (13824149..13827323)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13825543..13826861)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210 member A Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene RNA guanine-7 methyltransferase Neighboring gene melanocortin 2 receptor Neighboring gene ribosomal protein L36a pseudogene 49

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone binding IEA
Inferred from Electronic Annotation
more info
 
melanocortin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005913.3NP_005904.1  melanocortin receptor 5

    See identical proteins and their annotated locations for NP_005904.1

    Status: VALIDATED

    Source sequence(s)
    AP001525, BC069153, DR002771
    Consensus CDS
    CCDS11868.1
    UniProtKB/Swiss-Prot
    P33032
    UniProtKB/TrEMBL
    K7ER30
    Related
    ENSP00000468086.2, ENST00000589410.2
    Conserved Domains (2) summary
    pfam00001
    Location:53295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:43167
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    13824149..13827323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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