Hsc70-2 Heat shock protein 70 cognate 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsc70-2provided by FlyBase
Official Full Name: Heat shock protein 70 cognate 2provided by FlyBase
Primary source: FLYBASE:FBgn0001217
Locus tag: Dmel_CG7756
See related: AllianceGenome:FB:FBgn0001217
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7756; dhsc70; Dmel\CG7756; Hsc-2; HSC-70; hsc2; Hsc2; HSC2; hsc70; Hsc70; HSC70; HSC70-2; Hsc70.2; hsp70; HSP70cA8; HSP7B_DROME
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; systemic lupus erythematosus; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA6 (heat shock protein family A (Hsp70) member 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 87D10-87D10; 3-53 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13044759..13047388)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8870481..8873110)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 70 cognate 2

Names: 70 kDa heat shock protein, cytosolic A 8; CG7756-PA; Hs protein cognate 2; Hsc70-2-PA; Hsp cognate 2; heat shock protein cognate 2; heat shock protein cognate-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13044759..13047388

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079615.4 → NP_524339.1 heat shock protein 70 cognate 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524339.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11146, Q5U0V1, Q9VFZ5

Related

FBpp0082175

Conserved Domains (2) summary

cd10233
Location:6 → 382

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 632

PTZ00009; heat shock 70 kDa protein; Provisional