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Hsc70-2 Heat shock protein cognate 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41609, updated on 11-Aug-2022

Summary

Official Symbol
Hsc70-2provided by FlyBase
Official Full Name
Heat shock protein cognate 2provided by FlyBase
Primary source
FLYBASE:FBgn0001217
Locus tag
Dmel_CG7756
See related
AllianceGenome:FB:FBgn0001217
Gene type
protein coding
RNA name
heat shock protein cognate 2
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7756; dhsc70; Dmel\CG7756; Hsc-2; HSC-70; hsc2; Hsc2; HSC2; hsc70; Hsc70; HSC70; HSC70-2; Hsc70.2; HSP7B_DROME
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; systemic lupus erythematosus; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA6 (heat shock protein family A (Hsp70) member 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Hsc70-2 in Genome Data Viewer
Location:
87D10-87D10; 3-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13044759..13047388)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8870481..8873110)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene snake Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Hsc70-2 gene: The Hsc70-2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heat shock protein cognate 2
Names
CG7756-PA
Hs protein cognate 2
Hsc70-2-PA
Hsp cognate 2
heat shock protein cognate-2
NP_524339.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13044759..13047388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079615.4NP_524339.1  heat shock protein cognate 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11146, Q9VFZ5
    Related
    FBpp0082175, FBtr0082707
    Conserved Domains (2) summary
    cd10233
    Location:6382
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1632
    PTZ00009; heat shock 70 kDa protein; Provisional