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MBD1 methyl-CpG binding domain protein 1 [ Homo sapiens (human) ]

Gene ID: 4152, updated on 13-Jan-2019

Summary

Official Symbol
MBD1provided by HGNC
Official Full Name
methyl-CpG binding domain protein 1provided by HGNC
Primary source
HGNC:HGNC:6916
See related
Ensembl:ENSG00000141644 MIM:156535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFT; PCM1; CXXC3
Summary
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 18.8), bone marrow (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See MBD1 in Genome Data Viewer
Location:
18q21.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (50266882..50281774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47793252..47808144, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 310, pseudogene Neighboring gene cilia and flagella associated protein 53 Neighboring gene CXXC finger protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 458

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
methyl-CpG binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
methylation-dependent chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
methyl-CpG-binding domain protein 1
Names
CXXC-type zinc finger protein 3
methyl-CpG binding domain protein 1 isoform PCM1
protein containing methyl-CpG-binding domain 1
the regulator of fibroblast growth factor 2 (FGF-2) transcription

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029505.1 RefSeqGene

    Range
    5001..19893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204136.1NP_001191065.1  methyl-CpG-binding domain protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a longer isoform (6) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK291519, AK302004, CD723822
    Consensus CDS
    CCDS59320.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000468785.1, ENST00000590208.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  2. NM_001204137.1NP_001191066.1  methyl-CpG-binding domain protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001191066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an additional in-frame coding exon, and has a different 3' UTR compared to variant 1. This results in a longer isoform (7, also known as RFT-A) with an extra protein segment not found in isoform 1. This isoform has been shown to repress FGF-2 expression at the transcriptional level, and may be involved in FGF-2-dependent tumor progression (PMID:10187827).
    Source sequence(s)
    AK291519, AK295401, AK302004, BP384783
    Consensus CDS
    CCDS56073.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    A8K654, B4DI41
    Related
    ENSP00000405268.2, ENST00000457839.6
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  3. NM_001204138.1NP_001191067.1  methyl-CpG-binding domain protein 1 isoform 8

    See identical proteins and their annotated locations for NP_001191067.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is the same as variant 7, except uses an alternate acceptor splice site at one of the coding exons, resulting in an isoform (8, also known as RFT-Aprime) that is 1 aa shorter than isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
    Source sequence(s)
    AK291519, AK295401, AK302004, BP384783
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    A8K654, B4DI41
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  4. NM_001204139.1NP_001191068.1  methyl-CpG-binding domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001191068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) contains an alternate 3' terminal non-coding exon, thus has a different 3' UTR compared to variant 1. Variants 1 and 14 encode the same isoform (1).
    Source sequence(s)
    AK291519, AK302004, BC047353
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000372407.5, ENST00000382948.9
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  5. NM_001204140.1NP_001191069.1  methyl-CpG-binding domain protein 1 isoform 9

    See identical proteins and their annotated locations for NP_001191069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is the same as variant 7, except lacks an in-frame coding exon, resulting in an isoform (9, also known as RFT-B) that is missing an internal protein segment compared to isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
    Source sequence(s)
    AK291519, AK295401, AK302004, BP384783
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    A8K654, B4DI41
    Related
    ENSP00000381508.2, ENST00000398495.6
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  6. NM_001204141.1NP_001191070.1  methyl-CpG-binding domain protein 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks 2 non-consecutive coding exons, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (10) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK225889, AK291519, AK302004, BC047353
    Consensus CDS
    CCDS59318.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000466092.1, ENST00000585672.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:281327
    zf-CXXC; CXXC zinc finger domain
  7. NM_001204142.1NP_001191071.1  methyl-CpG-binding domain protein 1 isoform 11

    See identical proteins and their annotated locations for NP_001191071.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks 3 non-consecutive coding exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (11) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF078831, AJ564845, AK291519, CD723822
    Consensus CDS
    CCDS56072.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    A8K654
    Related
    ENSP00000339546.5, ENST00000339998.10
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  8. NM_001204143.1NP_001191072.1  methyl-CpG-binding domain protein 1 isoform 12

    See identical proteins and their annotated locations for NP_001191072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks 3 non-consecutive coding exons, and uses an alternate donor splice site at the 5' non-coding exon and an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (12) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF078831, AJ564845, AK300759, CD723822
    Consensus CDS
    CCDS59319.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    UniProtKB/TrEMBL
    B4DUR3
    Related
    ENSP00000468042.1, ENST00000587605.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  9. NM_001204151.2NP_001191080.1  methyl-CpG-binding domain protein 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) lacks 2 non-consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (13) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AC090246
    Consensus CDS
    CCDS56071.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000465923.1, ENST00000591535.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:308354
    zf-CXXC; CXXC zinc finger domain
  10. NM_001323942.1NP_001310871.1  methyl-CpG-binding domain protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  11. NM_001323947.1NP_001310876.1  methyl-CpG-binding domain protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  12. NM_001323949.1NP_001310878.1  methyl-CpG-binding domain protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC090246
  13. NM_001323950.1NP_001310879.1  methyl-CpG-binding domain protein 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC090246
  14. NM_001323951.1NP_001310880.1  methyl-CpG-binding domain protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC090246
  15. NM_001323952.1NP_001310881.1  methyl-CpG-binding domain protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC090246
  16. NM_001323953.1NP_001310882.1  methyl-CpG-binding domain protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC090246
  17. NM_001323954.1NP_001310883.1  methyl-CpG-binding domain protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC090246
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  18. NM_002384.2NP_002375.1  methyl-CpG-binding domain protein 1 isoform 4

    See identical proteins and their annotated locations for NP_002375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks 2 in-frame non-consecutive coding exons compared to variant 1, resulting in a shorter isoform (4) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11941.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000381502.1, ENST00000398488.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  19. NM_015844.2NP_056669.2  methyl-CpG-binding domain protein 1 isoform 3

    See identical proteins and their annotated locations for NP_056669.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11942.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000285102.5, ENST00000347968.7
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  20. NM_015845.3NP_056670.2  methyl-CpG-binding domain protein 1 isoform 2

    See identical proteins and their annotated locations for NP_056670.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing 3 non-consecutive coding exons compared to variant 1, the last of which causes a frame-shift. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS32832.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000269471.5, ENST00000269471.9
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:308354
    zf-CXXC; CXXC zinc finger domain
  21. NM_015846.3NP_056671.2  methyl-CpG-binding domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056671.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 14 encode the same isoform.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000269468.5, ENST00000269468.9
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  22. NM_015847.3NP_056723.2  methyl-CpG-binding domain protein 1 isoform 5

    See identical proteins and their annotated locations for NP_056723.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (5) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11944.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000269469.5, ENST00000353909.7
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:282328
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    50266882..50281774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025775.2XP_016881264.1  methyl-CpG-binding domain protein 1 isoform X30

  2. XM_017025772.2XP_016881261.1  methyl-CpG-binding domain protein 1 isoform X27

  3. XM_017025768.2XP_016881257.1  methyl-CpG-binding domain protein 1 isoform X23

  4. XM_017025777.2XP_016881266.1  methyl-CpG-binding domain protein 1 isoform X33

  5. XM_017025755.2XP_016881244.1  methyl-CpG-binding domain protein 1 isoform X11

  6. XM_024451182.1XP_024306950.1  methyl-CpG-binding domain protein 1 isoform X28

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  7. XM_024451179.1XP_024306947.1  methyl-CpG-binding domain protein 1 isoform X19

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  8. XM_017025761.2XP_016881250.1  methyl-CpG-binding domain protein 1 isoform X18

  9. XM_017025754.2XP_016881243.1  methyl-CpG-binding domain protein 1 isoform X9

  10. XM_024451175.1XP_024306943.1  methyl-CpG-binding domain protein 1 isoform X3

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  11. XM_011526006.2XP_011524308.1  methyl-CpG-binding domain protein 1 isoform X29

    See identical proteins and their annotated locations for XP_011524308.1

    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  12. XM_017025776.2XP_016881265.1  methyl-CpG-binding domain protein 1 isoform X31

    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  13. XM_017025765.2XP_016881254.1  methyl-CpG-binding domain protein 1 isoform X21

  14. XM_011526001.2XP_011524303.1  methyl-CpG-binding domain protein 1 isoform X17

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  15. XM_017025770.2XP_016881259.1  methyl-CpG-binding domain protein 1 isoform X26

    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000381506.1, ENST00000398493.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  16. XM_011525999.2XP_011524301.1  methyl-CpG-binding domain protein 1 isoform X14

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  17. XM_017025769.2XP_016881258.1  methyl-CpG-binding domain protein 1 isoform X24

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  18. XM_011526007.2XP_011524309.1  methyl-CpG-binding domain protein 1 isoform X24

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  19. XM_017025752.2XP_016881241.1  methyl-CpG-binding domain protein 1 isoform X4

  20. XM_017025753.2XP_016881242.1  methyl-CpG-binding domain protein 1 isoform X5

  21. XM_017025760.2XP_016881249.1  methyl-CpG-binding domain protein 1 isoform X16

    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  22. XM_005258271.3XP_005258328.1  methyl-CpG-binding domain protein 1 isoform X16

    See identical proteins and their annotated locations for XP_005258328.1

    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000467017.1, ENST00000591416.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  23. XM_024451181.1XP_024306949.1  methyl-CpG-binding domain protein 1 isoform X25

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  24. XM_024451180.1XP_024306948.1  methyl-CpG-binding domain protein 1 isoform X25

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  25. XM_024451178.1XP_024306946.1  methyl-CpG-binding domain protein 1 isoform X15

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  26. XM_024451177.1XP_024306945.1  methyl-CpG-binding domain protein 1 isoform X10

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  27. XM_017025767.2XP_016881256.1  methyl-CpG-binding domain protein 1 isoform X22

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  28. XM_017025766.2XP_016881255.1  methyl-CpG-binding domain protein 1 isoform X22

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  29. XM_024451176.1XP_024306944.1  methyl-CpG-binding domain protein 1 isoform X8

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:355401
    zf-CXXC; CXXC zinc finger domain
  30. XM_017025756.2XP_016881245.1  methyl-CpG-binding domain protein 1 isoform X12

  31. XM_011525991.2XP_011524293.1  methyl-CpG-binding domain protein 1 isoform X6

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  32. XM_017025764.2XP_016881253.1  methyl-CpG-binding domain protein 1 isoform X20

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  33. XM_011526003.3XP_011524305.1  methyl-CpG-binding domain protein 1 isoform X20

    See identical proteins and their annotated locations for XP_011524305.1

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  34. XM_011526002.2XP_011524304.1  methyl-CpG-binding domain protein 1 isoform X20

    See identical proteins and their annotated locations for XP_011524304.1

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  35. XM_017025751.2XP_016881240.1  methyl-CpG-binding domain protein 1 isoform X2

  36. XM_017025759.2XP_016881248.1  methyl-CpG-binding domain protein 1 isoform X13

  37. XM_017025758.2XP_016881247.1  methyl-CpG-binding domain protein 1 isoform X13

  38. XM_017025757.2XP_016881246.1  methyl-CpG-binding domain protein 1 isoform X13

  39. XM_006722456.3XP_006722519.1  methyl-CpG-binding domain protein 1 isoform X1

    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  40. XM_011525993.3XP_011524295.1  methyl-CpG-binding domain protein 1 isoform X7

    See identical proteins and their annotated locations for XP_011524295.1

    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000468430.1, ENST00000585595.5
    Conserved Domains (2) summary
    smart00391
    Location:376
    MBD; Methyl-CpG binding domain
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  41. XM_024451183.1XP_024306951.1  methyl-CpG-binding domain protein 1 isoform X32

    Conserved Domains (1) summary
    pfam02008
    Location:146
    zf-CXXC; CXXC zinc finger domain
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